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    Lipt1 lipoyltransferase 1 [ Mus musculus (house mouse) ]

    Gene ID: 623661, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Lipt1provided by MGI
    Official Full Name
    lipoyltransferase 1provided by MGI
    Primary source
    MGI:MGI:3645211
    See related
    Ensembl:ENSMUSG00000037216 AllianceGenome:MGI:3645211
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    EG623661
    Summary
    Predicted to enable lipoyltransferase activity. Predicted to be involved in protein lipoylation. Located in mitochondrion. Is expressed in embryo. Orthologous to human LIPT1 (lipoyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
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    Genomic context

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    See Lipt1 in Genome Data Viewer
    Location:
    1 B; 1 16.13 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (37910819..37915309)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (37871738..37876228)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene capping protein inhibiting regulator of actin like Neighboring gene predicted gene, 39628 Neighboring gene testis specific 10 Neighboring gene STARR-seq mESC enhancer starr_00684 Neighboring gene STARR-positive B cell enhancer mm9_chr1:37921599-37921900 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:37922129-37922238 Neighboring gene MIT, microtubule interacting and transport, domain containing 1 Neighboring gene mitochondrial ribosomal protein L30 Neighboring gene lysozyme G-like 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mitochondrial fatty acid synthesis coordinates oxidative metabolism in mammalian mitochondria. Nowinski SM, et al. Elife, 2020 Aug 17. PMID 32804083, Free PMC Article
    2. Protein moonlighting elucidates the essential human pathway catalyzing lipoic acid assembly on its cognate enzymes. Cao X, et al. Proc Natl Acad Sci U S A, 2018 Jul 24. PMID 29987032, Free PMC Article
    3. Compromised mitochondrial fatty acid synthesis in transgenic mice results in defective protein lipoylation and energy disequilibrium. Smith S, et al. PLoS One, 2012. PMID 23077570, Free PMC Article
    4. Functional Assessment of Lipoyltransferase-1 Deficiency in Cells, Mice, and Humans. Ni M, et al. Cell Rep, 2019 Apr 30. PMID 31042466, Free PMC Article
    5. Compartmentalized metabolism supports midgestation mammalian development. Solmonson A, et al. Nature, 2022 Apr. PMID 35388219, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC28431

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables N-acyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables lipoyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lipoyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein lipoylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    lipoyl amidotransferase LIPT1, mitochondrial
    Names
    lipoate biosynthesis protein
    lipoate-protein ligase
    lipoyl ligase
    lipoyltransferase 1, mitochondrial
    NP_001033007.2
    NP_001363958.1
    NP_001363959.1
    NP_001363960.1
    NP_001363961.1
    NP_001363962.1
    NP_001363963.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037918.5 → NP_001033007.2  lipoyl amidotransferase LIPT1, mitochondrial precursor

      See identical proteins and their annotated locations for NP_001033007.2

      Status: VALIDATED

      Source sequence(s)
      AC119189
      Consensus CDS
      CCDS14895.1
      UniProtKB/Swiss-Prot
      Q8VCM4
      UniProtKB/TrEMBL
      Q8C894
      Related
      ENSMUSP00000038739.4, ENSMUST00000041621.5
      Conserved Domains (1) summary
      cd16443
      Location:33 → 235
      LplA; lipoate-protein ligase

    2. NM_001377029.2 → NP_001363958.1  lipoyl amidotransferase LIPT1, mitochondrial precursor

      Status: VALIDATED

      Source sequence(s)
      AC119189
      UniProtKB/Swiss-Prot
      Q8VCM4
      UniProtKB/TrEMBL
      Q8C894
      Conserved Domains (1) summary
      cd16443
      Location:33 → 235
      LplA; lipoate-protein ligase

    3. NM_001377030.2 → NP_001363959.1  lipoyl amidotransferase LIPT1, mitochondrial precursor

      Status: VALIDATED

      Source sequence(s)
      AC119189
      UniProtKB/Swiss-Prot
      Q8VCM4
      UniProtKB/TrEMBL
      Q8C894
      Conserved Domains (1) summary
      cd16443
      Location:33 → 235
      LplA; lipoate-protein ligase

    4. NM_001377031.2 → NP_001363960.1  lipoyl amidotransferase LIPT1, mitochondrial precursor

      Status: VALIDATED

      Source sequence(s)
      AC119189
      UniProtKB/Swiss-Prot
      Q8VCM4
      UniProtKB/TrEMBL
      Q8C894
      Conserved Domains (1) summary
      cd16443
      Location:33 → 235
      LplA; lipoate-protein ligase

    5. NM_001377032.2 → NP_001363961.1  lipoyl amidotransferase LIPT1, mitochondrial precursor

      Status: VALIDATED

      Source sequence(s)
      AC119189
      UniProtKB/Swiss-Prot
      Q8VCM4
      UniProtKB/TrEMBL
      Q8C894
      Conserved Domains (1) summary
      cd16443
      Location:33 → 235
      LplA; lipoate-protein ligase

    6. NM_001377033.2 → NP_001363962.1  lipoyl amidotransferase LIPT1, mitochondrial precursor

      Status: VALIDATED

      Source sequence(s)
      AC119189
      UniProtKB/Swiss-Prot
      Q8VCM4
      UniProtKB/TrEMBL
      Q8C894
      Conserved Domains (1) summary
      cd16443
      Location:33 → 235
      LplA; lipoate-protein ligase

    7. NM_001377034.2 → NP_001363963.1  lipoyl amidotransferase LIPT1, mitochondrial precursor

      Status: VALIDATED

      Source sequence(s)
      AC119189
      UniProtKB/Swiss-Prot
      Q8VCM4
      UniProtKB/TrEMBL
      Q8C894
      Conserved Domains (1) summary
      cd16443
      Location:33 → 235
      LplA; lipoate-protein ligase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      37910819..37915309
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VCM4.1 GenPept UniProtKB/Swiss-Prot:Q8VCM4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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