Hoxc8 homeobox C8 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hoxc8provided by MGI
Official Full Name: homeobox C8provided by MGI
Primary source: MGI:MGI:96198
See related: Ensembl:ENSMUSG00000001657 AllianceGenome:MGI:96198
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Hox-3.1; D130011F21Rik
Summary: Enables DNA binding activity. Acts upstream of or within several processes, including anterior/posterior pattern specification; negative regulation of transcription by RNA polymerase II; and skeletal system morphogenesis. Located in nucleus. Is expressed in several structures, including alimentary system; embryo mesenchyme; genitourinary system; integumental system; and nervous system. Orthologous to human HOXC8 (homeobox C8). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in genital fat pad adult (RPKM 8.3), subcutaneous fat pad adult (RPKM 6.3) and 10 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 F3; 15 58.05 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (102898971..102902707)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (102990539..102994275)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In presence of these inducing agents, lipid accumulation as well as expression of HoxA1, HoxA5, HoxC4 &HoxC8 markedly enhanced. Irrespective of presence or absence of T3, insulin down regulates HoxA10. T3 results in over expression of HoxA5, HoxC4 and HoxC8 genes, whereas insulin up regulates expression of only HoxC8
Title: Fat accumulation in differentiated brown adipocytes is linked with expression of Hox genes.
Hoxc8 initiates an ectopic mammary program by regulating Fgf10 and Tbx3 expression and Wnt/beta-catenin signaling
Title: Hoxc8 initiates an ectopic mammary program by regulating Fgf10 and Tbx3 expression and Wnt/β-catenin signaling.
Cdx1 regulation on HoxC8 expression and suggest the possibility that the temporal changes in Cdx activity levels during gastrulation, combined with differential DNA binding affinity, might play a role in the establishment of Hox sequential activation.
Title: Cdx1 is essential for the initiation of HoxC8 expression during early embryogenesis.
Hoxc8 downregulates Mgl1 tumor suppressor gene expression and reduces its concomitant function on cell adhesion.
Title: Hoxc8 downregulates Mgl1 tumor suppressor gene expression and reduces its concomitant function on cell adhesion.
Data provide the basis for future studies in pathogenesis of cartilage defects in Hoxc8- and Hoxd4-transgenic mice.
Title: Expression of cartilage developmental genes in Hoxc8- and Hoxd4-transgenic mice.
Hoxc8, when over-expressed in C3H10T1/2 or C2C12 cells, suppressed basal Smad6 promoter activity and its mRNA expression
Title: Hoxc8 represses BMP-induced expression of Smad6.
Hoxc8 regulation is essential for osteoblast differentiation.
Title: In vitro osteoblast differentiation is negatively regulated by Hoxc8.
Pcna is a direct downstream target of Hoxc8.
Title: Proliferating cell nuclear antigen (Pcna) as a direct downstream target gene of Hoxc8.
Our results provide evidence for a role for Hoxc8 in controlling cell cycle progression
Title: Morpholino-mediated knockdown in primary chondrocytes implicates Hoxc8 in regulation of cell cycle progression.
These results indicate that the 16 amino acid third helix is the key element responsible for the membrane transduction activity of Hoxc8 proteins.
Title: The third helix of the murine Hoxc8 homeodomain facilitates protein transduction in mammalian cells.

Submit: New GeneRIF Correction See all GeneRIFs (18)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (7) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D15Mit15 (e-PCR), detects polymorphism
- UniSTS:127513

D7wox32 (e-PCR)
- UniSTS:143387

Hoxc (e-PCR), detects polymorphism
- UniSTS:143387

NoName (e-PCR)
- UniSTS:484894

Hoxc8 (e-PCR), detects polymorphism
- UniSTS:143391

MARC_41665-41666:1086710236:1 (e-PCR)
- UniSTS:471605

Hoxc8 (e-PCR), detects polymorphism
- UniSTS:536664

Hoxc8 (e-PCR), detects polymorphism
- UniSTS:547242

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables sequence-specific double-stranded DNA binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within anterior/posterior pattern specification	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within anterior/posterior pattern specification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within skeletal system morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within skeletal system morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in microtubule cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in microtubule cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: homeobox protein Hox-C8

Names: homeo box C8; homeobox protein Hox-3.1; homeobox protein M31

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010466.2 → NP_034596.1 homeobox protein Hox-C8

See identical proteins and their annotated locations for NP_034596.1

Status: VALIDATED

Source sequence(s)

AC021667

Consensus CDS

CCDS27894.1

UniProtKB/Swiss-Prot

P09025

Related

ENSMUSP00000001703.7, ENSMUST00000001703.8

Conserved Domains (1) summary

pfam00046
Location:153 → 206

Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

102898971..102902707

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030248341.2 → XP_030104201.1 homeobox protein Hox-C8 isoform X1

Conserved Domains (1) summary

pfam00046
Location:16 → 69

Homeobox; Homeobox domain