Tpra1 transmembrane protein, adipocyte asscociated 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tpra1provided by MGI
Official Full Name: transmembrane protein, adipocyte asscociated 1provided by MGI
Primary source: MGI:MGI:1345190
See related: Ensembl:ENSMUSG00000002871 AllianceGenome:MGI:1345190
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 40kDa; Gpr175; Tpra40
Summary: Predicted to enable G protein-coupled receptor activity. Acts upstream of or within embryonic cleavage and negative regulation of mitotic cell cycle phase transition. Predicted to be active in plasma membrane. Is expressed in brain. Orthologous to human TPRA1 (transmembrane protein adipocyte associated 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in adrenal adult (RPKM 50.6), ovary adult (RPKM 24.2) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 D1; 6 39.65 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (88879238..88889216)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (88902251..88912240)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the functional plasma membrane transport of TPRA40 that regulates cell division of mouse embryos is mediated by NA14.
Title: TPRA40/GPR175 regulates early mouse embryogenesis through functional membrane transport by Sjögren's syndrome-associated protein NA14.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (1)
Targeted (1)

General gene information

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Markers

Tpra1 (e-PCR), detects polymorphism
- UniSTS:547475

RH130646 (e-PCR)
- UniSTS:213930

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within embryonic cleavage	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of mitotic cell cycle phase transition	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: transmembrane protein adipocyte-associated 1

Names: G protein-coupled receptor 175; integral membrane protein GPR175; transmembrane domain protein of 40 kDa regulated in adipocytes; transmembrane domain protein regulated in adipocytes 40 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001410580.1 → NP_001397509.1 transmembrane protein adipocyte-associated 1 isoform 2

Status: VALIDATED

Source sequence(s)

AC153923
NM_001410581.1 → NP_001397510.1 transmembrane protein adipocyte-associated 1 isoform 3

Status: VALIDATED

Source sequence(s)

AC153923
NM_011906.3 → NP_036036.2 transmembrane protein adipocyte-associated 1 isoform 1

See identical proteins and their annotated locations for NP_036036.2

Status: VALIDATED

Source sequence(s)

AC153923

Consensus CDS

CCDS39555.1

UniProtKB/Swiss-Prot

Q80UD9, Q8C240, Q91Z36, Q99MU1, Q9Z112

Related

ENSMUSP00000145050.2, ENSMUST00000204765.3

Conserved Domains (1) summary

pfam10160
Location:36 → 309

Tmemb_40; Predicted membrane protein