TAD3 Tad3p [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: TAD3
Official Full Name: Tad3p
Primary source: SGD:S000004308
Locus tag: YLR316C
See related: AllianceGenome:SGD:S000004308; FungiDB:YLR316C; VEuPathDB:YLR316C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables tRNA-specific adenosine deaminase activity. Involved in tRNA modification. Located in peroxisome. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with brain abnormalities, poor growth, and dysmorphic facies. Orthologous to human ADAT3 (adenosine deaminase tRNA specific 3). [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome XII - NC_001144.5 Genomic Context describing neighboring genes

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The CGA codon decoding through tRNA[Arg] (ICG) supply governed by Tad2/Tad3 in Saccharomyces cerevisiae.
Title: The CGA codon decoding through tRNA(Arg) (ICG) supply governed by Tad2/Tad3 in Saccharomyces cerevisiae.
Crystal structure of the ADAT2-ADAT3 heterodimer. [ADAT2, ADAT3]
Title: Biochemical and structural studies of A-to-I editing by tRNA:A34 deaminases at the wobble position of transfer RNA.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables deaminase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	IEA Inferred from Electronic Annotation more info
enables tRNA-specific adenosine deaminase activity	IDA Inferred from Direct Assay more info	PubMed
contributes_to tRNA-specific adenosine-34 deaminase activity	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	RCA inferred from Reviewed Computational Analysis more info	PubMed

Process	Evidence Code	Pubs
involved_in nucleobase-containing compound biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in tRNA modification	IDA Inferred from Direct Assay more info	PubMed
involved_in tRNA processing	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in peroxisome	IDA Inferred from Direct Assay more info	PubMed

NP_013420.2

Subunit of tRNA-specific adenosine-34 deaminase; forms a heterodimer with Tad2p that converts adenosine to inosine at the wobble position of several tRNAs; localizes to cytosol, nucleus and peroxisomes

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The following sections contain reference sequences that belong to a specific genome build. Explain