IRC20 E3 ubiquitin-protein ligase IRC20 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: IRC20
Official Full Name: E3 ubiquitin-protein ligase IRC20
Primary source: SGD:S000004237
Locus tag: YLR247C
See related: AllianceGenome:SGD:S000004237; FungiDB:YLR247C; VEuPathDB:YLR247C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables ubiquitin-protein transferase activity. Involved in double-strand break repair via nonhomologous end joining and double-strand break repair via synthesis-dependent strand annealing. Located in mitochondrion and nucleus. Orthologous to human SHPRH (SNF2 histone linker PHD RING helicase). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See IRC20 in Genome Data Viewer

Location:: chromosome: XII

Exon count:: 1

Sequence:: Chromosome: XII; NC_001144.5 (628684..633354, complement)

Chromosome XII - NC_001144.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Irc20 modulates LOH frequency and distribution in S. cerevisiae.
Title: Irc20 modulates LOH frequency and distribution in S. cerevisiae.
The ATPase Irc20 facilitates Rad51 chromatin enrichment during homologous recombination in yeast Saccharomyces cerevisiae.
Title: The ATPase Irc20 facilitates Rad51 chromatin enrichment during homologous recombination in yeast Saccharomyces cerevisiae.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D1S3698 (e-PCR)
- UniSTS:474276

Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP-dependent activity, acting on DNA	IBA Inferred from Biological aspect of Ancestor more info
enables helicase activity	IEA Inferred from Electronic Annotation more info
enables helicase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin-protein transferase activity	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin-protein transferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables zinc ion binding	RCA inferred from Reviewed Computational Analysis more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA repair	IBA Inferred from Biological aspect of Ancestor more info
involved_in double-strand break repair via nonhomologous end joining	IGI Inferred from Genetic Interaction more info	PubMed
involved_in double-strand break repair via synthesis-dependent strand annealing	IGI Inferred from Genetic Interaction more info	PubMed
involved_in double-strand break repair via synthesis-dependent strand annealing	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrion	HDA more info	PubMed
located_in nucleus	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase IRC20

NP_013348.1

E3 ubiquitin ligase and putative helicase; involved in synthesis-dependent strand annealing-mediated homologous recombination; ensures precise end-joining along with Srs2p in the Yku70p/Yku80p/Lig4p-dependent NHEJ pathway; controls 2-micron plasmid copy number by regulating the levels of the Flp1p recombinase; localizes to both the mitochondrion and the nucleus; contains a Snf2/Swi2 family ATPase/helicase and a RING finger domain; null mutant displays increased levels of spontaneous Rad52p foci

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001144.5 Reference assembly

Range

628684..633354 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001182134.1 → NP_013348.1 TPA: E3 ubiquitin-protein ligase IRC20 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_013348.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VYP5, Q06554

UniProtKB/TrEMBL

A7A1D0, N1P1E7

Conserved Domains (5) summary

COG0553
Location:172 → 568

HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]

COG5432
Location:1234 → 1327

RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]

cd16536
Location:1239 → 1276

RING-HC_RNF10; RING finger, HC subclass, found in RING finger protein 10 (RNF10) and similar proteins

cd18793
Location:1356 → 1485

SF2_C_SNF; C-terminal helicase domain of the SNF family helicases

cd18070
Location:383 → 602

DEXQc_SHPRH; DEXQ-box helicase domain of SHPRH