MRT4 Mrt4p [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: MRT4
Official Full Name: Mrt4p
Primary source: SGD:S000001492
Locus tag: YKL009W
See related: AllianceGenome:SGD:S000001492; FungiDB:YKL009W; VEuPathDB:YKL009W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Predicted to enable large ribosomal subunit rRNA binding activity. Involved in nuclear-transcribed mRNA catabolic process and ribosome biogenesis. Located in nucleolus and nucleoplasm. Part of preribosome, large subunit precursor. Orthologous to human MRTO4 (MRT4 homolog, ribosome maturation factor). [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome XI - NC_001143.9 Genomic Context describing neighboring genes

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the interaction between Mrt4 and Yvh1 is also essential for normal glycogen accumulation and mRNA decay as well as the induction of sporulation genes
Title: Genetic interactions of ribosome maturation factors Yvh1 and Mrt4 influence mRNA decay, glycogen accumulation, and the expression of early meiotic genes in Saccharomyces cerevisiae.
loss of function of Mrt4 results in a deficit in 60S subunits, which is apparently due to impaired rRNA processing of 27S precursors
Title: Role and dynamics of the ribosomal protein P0 and its related trans-acting factor Mrt4 during ribosome assembly in Saccharomyces cerevisiae.
Ribosome stalk assembly requires the dual-specificity phosphatase Yvh1 for the exchange of Mrt4 with P0.
Title: Ribosome stalk assembly requires the dual-specificity phosphatase Yvh1 for the exchange of Mrt4 with P0.
results indicate that Mrt4 and P0 bind to the same site in the 25S rRNA.
Title: The amino terminal domain from Mrt4 protein can functionally replace the RNA binding domain of the ribosomal P0 protein.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables large ribosomal subunit rRNA binding	ISA Inferred from Sequence Alignment more info	PubMed

Process	Evidence Code	Pubs
involved_in nuclear-transcribed mRNA catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in nuclear-transcribed mRNA catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in rRNA processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in rRNA processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ribosomal large subunit assembly	IEA Inferred from Electronic Annotation more info
involved_in ribosomal large subunit biogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in ribosomal large subunit biogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ribosomal large subunit export from nucleus	IGI Inferred from Genetic Interaction more info	PubMed
involved_in ribosomal large subunit export from nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ribosome biogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleolus	HDA more info	PubMed
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	HDA more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of preribosome, large subunit precursor	HDA more info	PubMed
part_of preribosome, large subunit precursor	IBA Inferred from Biological aspect of Ancestor more info
part_of preribosome, large subunit precursor	IDA Inferred from Direct Assay more info	PubMed

NP_012916.1

Protein involved in mRNA turnover and ribosome assembly; required at post-transcriptional step for efficient retrotransposition; localizes to the nucleolus

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The following sections contain reference sequences that belong to a specific genome build. Explain