VPS8 CORVET complex membrane-binding subunit VPS8 [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: VPS8
Official Full Name: CORVET complex membrane-binding subunit VPS8
Primary source: SGD:S000000002
Locus tag: YAL002W
See related: AllianceGenome:SGD:S000000002; FungiDB:YAL002W; VEuPathDB:YAL002W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: FUN15; VPL8; VPT8
Summary: Enables GTPase binding activity and protein-membrane adaptor activity. Involved in late endosome to vacuole transport via multivesicular body sorting pathway and protein targeting to vacuole. Located in late endosome and membrane. Part of CORVET complex. Orthologous to human VPS8 (VPS8 subunit of CORVET complex). [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome I - NC_001133.9 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

C-terminal alpha-helical segments of VPS3 and VPS8 are necessary for CORVET assembly and function.
Title: The N-terminal domains of Vps3 and Vps8 are critical for localization and function of the CORVET tethering complex on endosomes.
Data suggest that the Vps21 interaction is not essential for endosomal trafficking but may be important for some other aspect of Vps8 function.
Title: Mapping of Vps21 and HOPS binding sites in Vps8 and effect of binding site mutants on endocytic trafficking.
Vps8 interacts and cooperates with the activated Rab5 homolog Vps21 to induce the clustering of late endosomal membranes
Title: The CORVET subunit Vps8 cooperates with the Rab5 homolog Vps21 to induce clustering of late endosomal compartments.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables GTPase binding	IDA Inferred from Direct Assay more info	PubMed
enables GTPase binding	IPI Inferred from Physical Interaction more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein-membrane adaptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables zinc ion binding	RCA inferred from Reviewed Computational Analysis more info	PubMed

Process	Evidence Code	Pubs
involved_in endosomal vesicle fusion	IBA Inferred from Biological aspect of Ancestor more info
involved_in late endosome to vacuole transport via multivesicular body sorting pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein targeting to vacuole	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein targeting to vacuole	IEA Inferred from Electronic Annotation more info
involved_in protein targeting to vacuole	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in vesicle-mediated transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of CORVET complex	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi stack	IEA Inferred from Electronic Annotation more info
part_of HOPS complex	IBA Inferred from Biological aspect of Ancestor more info
located_in bounding membrane of organelle	IEA Inferred from Electronic Annotation more info
located_in endosome	IEA Inferred from Electronic Annotation more info
is_active_in late endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in late endosome	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
part_of vesicle tethering complex	IEA Inferred from Electronic Annotation more info

NP_009399.2

Membrane-binding component of the CORVET complex; involved in endosomal vesicle tethering and fusion in the endosome to vacuole protein targeting pathway; interacts with Vps21p; contains RING finger motif

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The following sections contain reference sequences that belong to a specific genome build. Explain