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    FLC3 putative flavin adenine dinucleotide transporter [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852738, updated on 9-Dec-2024

    Summary

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    Official Symbol
    FLC3
    Official Full Name
    putative flavin adenine dinucleotide transporter
    Primary source
    SGD:S000003107
    Locus tag
    YGL139W
    See related
    AllianceGenome:SGD:S000003107; FungiDB:YGL139W; VEuPathDB:YGL139W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable FAD transmembrane transporter activity. Involved in sphingolipid biosynthetic process. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See FLC3 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (245716..248124)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene ubiquitin-ubiquitin ligase HUL5 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene coatomer subunit beta'

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The sequence of a nearly unclonable 22.8 kb segment on the left arm chromosome VII from Saccharomyces cerevisiae reveals ARO2, RPL9A, TIP1, MRF1 genes and six new open reading frames. Voet M, et al. Yeast, 1997 Feb. PMID 9046099
    2. Hypotonic stress-induced calcium signaling in Saccharomyces cerevisiae involves TRP-like transporters on the endoplasmic reticulum membrane. Rigamonti M, et al. Cell Calcium, 2015 Feb. PMID 25573187
    3. Disruption of 12 ORFs located on chromosomes IV, VII and XIV of Saccharomyces cerevisiae reveals two essential genes. Volckaert G, et al. Yeast, 2003 Jan 15. PMID 12489128
    4. A screen for genes of heme uptake identifies the FLC family required for import of FAD into the endoplasmic reticulum. Protchenko O, et al. J Biol Chem, 2006 Jul 28. PMID 16717099
    5. A genome-wide screen in Saccharomyces cerevisiae reveals a critical role for the mitochondria in the toxicity of a trichothecene mycotoxin. McLaughlin JE, et al. Proc Natl Acad Sci U S A, 2009 Dec 22. PMID 20007368, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables FAD transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in FAD transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in FAD transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in fungal-type cell wall biogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sphingolipid biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    putative flavin adenine dinucleotide transporter
    NP_011376.3
    • Putative FAD transporter, similar to Flc1p and Flc2p; localized to the ER; FLC3 has a paralog, FLC1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      245716..248124
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181004.3 → NP_011376.3  TPA: putative flavin adenine dinucleotide transporter [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011376.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VU10, P53121
      UniProtKB/TrEMBL
      A6ZU44, C7GPR3, C8Z8B1, G2WDW4
      Conserved Domains (2) summary
      pfam06011
      Location:172 → 603
      TRP; Transient receptor potential (TRP) ion channel
      pfam14558
      Location:32 → 167
      TRP_N; ML-like domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53121.1

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