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    UTP20 Utp20p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852282, updated on 9-Dec-2024

    Summary

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    Official Symbol
    UTP20
    Official Full Name
    Utp20p
    Primary source
    SGD:S000000100
    Locus tag
    YBL004W
    See related
    AllianceGenome:SGD:S000000100; FungiDB:YBL004W; VEuPathDB:YBL004W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables mRNA binding activity. Involved in endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); and endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Located in cytoplasm; nucleolus; and nucleoplasm. Part of 90S preribosome; preribosome, small subunit precursor; and small-subunit processome. Orthologous to human UTP20 (UTP20 small subunit processome component). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See UTP20 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (227636..235117)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene gag protein Neighboring gene gag-pol fusion protein Neighboring gene tRNA-Ser Neighboring gene histone H2A Neighboring gene histone H2B

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Roles of the HEAT repeat proteins Utp10 and Utp20 in 40S ribosome maturation. Dez C, et al. RNA, 2007 Sep. PMID 17652137, Free PMC Article
    2. Synergistic defects in pre-rRNA processing from mutations in the U3-specific protein Rrp9 and U3 snoRNA. Clerget G, et al. Nucleic Acids Res, 2020 Apr 17. PMID 31996908, Free PMC Article
    3. In vitro structural maturation of an early stage pre-40S particle coupled with U3 snoRNA release and central pseudoknot formation. Cheng J, et al. Nucleic Acids Res, 2022 Nov 11. PMID 36263816, Free PMC Article
    4. Acetylation in histone H3 globular domain regulates gene expression in yeast. Xu F, et al. Cell, 2005 May 6. PMID 15882620
    5. Pi release from eIF2, not GTP hydrolysis, is the step controlled by start-site selection during eukaryotic translation initiation. Algire MA, et al. Mol Cell, 2005 Oct 28. PMID 16246727

    See all (71) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Required for pre-ribosomal RNA processing on the pathway of 18S synthesis.
      Title: Roles of the HEAT repeat proteins Utp10 and Utp20 in 40S ribosome maturation.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables mRNA binding HDA PubMed 
    Process Evidence Code Pubs
    involved_in endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of 90S preribosome HDA PubMed 
    part_of 90S preribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of 90S preribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus HDA PubMed 
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of preribosome, small subunit precursor IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of small-subunit processome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of small-subunit processome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Utp20p
    NP_009551.2
    • Component of the small-subunit (SSU) processome; SSU processome is involved in the biogenesis of the 18S rRNA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      227636..235117
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178244.1 → NP_009551.2  TPA: Utp20p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009551.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VPZ8, P35194
      UniProtKB/TrEMBL
      G2W905
      Conserved Domains (1) summary
      pfam07539
      Location:824 → 1407
      DRIM; Down-regulated in metastasis
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P35194.3

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