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    HOB2 Hob2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856233, updated on 9-Dec-2024

    Summary

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    Official Symbol
    HOB2
    Official Full Name
    Hob2p
    Primary source
    SGD:S000006321
    Locus tag
    YPR117W
    See related
    AllianceGenome:SGD:S000006321; FungiDB:YPR117W; VEuPathDB:YPR117W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to be located in endoplasmic reticulum membrane; mitochondrial membrane; and plasma membrane. Orthologous to human BLTP2 (bridge-like lipid transfer protein family member 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See HOB2 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (760025..767494)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Rgc1p Neighboring gene Rrg8p Neighboring gene S-methyl-5-thioribose-1-phosphate isomerase MRI1 Neighboring gene tRNA-Lys

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Hob proteins are novel and conserved lipid-binding proteins at ER-PM contact sites. Neuman SD, et al. J Cell Sci, 2022 Mar 1. PMID 34415038, Free PMC Article
    2. Comprehensive characterization of the Hsp70 interactome reveals novel client proteins and interactions mediated by posttranslational modifications. Nitika, et al. PLoS Biol, 2022 Oct. PMID 36269765, Free PMC Article
    3. Comprehensive and quantitative mapping of RNA-protein interactions across a transcribed eukaryotic genome. She R, et al. Proc Natl Acad Sci U S A, 2017 Apr 4. PMID 28325876, Free PMC Article
    4. Exploring genetic suppression interactions on a global scale. van Leeuwen J, et al. Science, 2016 Nov 4. PMID 27811238, Free PMC Article
    5. Saccharomyces cerevisiae Is Dependent on Vesicular Traffic between the Golgi Apparatus and the Vacuole When Inositolphosphorylceramide Synthase Aur1 Is Inactivated. Voynova NS, et al. Eukaryot Cell, 2015 Dec. PMID 26432633, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Hob2p
    NP_015442.1
    • Modulator of cellular lipid distribution; localizes to ER-PM and ER-mitochondria contact sites; shares homology with lipid transfer proteins Vps13p and Atg2p; homolog of D. melanogaster Hobbit protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      760025..767494
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184214.1 → NP_015442.1  TPA: Hob2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015442.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W4B6, Q06116
      UniProtKB/TrEMBL
      A6ZWZ8, B3LK81, C8ZJD9, N1NVL2
      Conserved Domains (5) summary
      pfam10293
      Location:792 → 944
      DUF2405; Domain of unknown function (DUF2405)
      pfam10305
      Location:974 → 1065
      Fmp27_SW; RNA pol II promoter Fmp27 protein domain
      pfam10347
      Location:1085 → 1234
      Fmp27_GFWDK; RNA pol II promoter Fmp27 protein domain
      pfam10351
      Location:1958 → 2401
      Apt1; Golgi-body localization protein domain
      pfam10359
      Location:1449 → 1945
      Fmp27_WPPW; RNA pol II promoter Fmp27 protein domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q06116.1

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