YPK9 putative acid anhydride hydrolase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: YPK9
Official Full Name: putative acid anhydride hydrolase
Primary source: SGD:S000005817
Locus tag: YOR291W
See related: AllianceGenome:SGD:S000005817; FungiDB:YOR291W; VEuPathDB:YOR291W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Predicted to enable ATPase-coupled monoatomic cation transmembrane transporter activity and P-type ion transporter activity. Predicted to be involved in intracellular calcium ion homeostasis and transmembrane transport. Located in fungal-type vacuole membrane and vacuole-mitochondrion membrane contact site. Used to study Kufor-Rakeb syndrome; amyotrophic lateral sclerosis; hereditary spastic paraplegia; juvenile-onset Parkinson's disease; and neuronal ceroid lipofuscinosis. Human ortholog(s) of this gene implicated in Kufor-Rakeb syndrome; Parkinson's disease; amyotrophic lateral sclerosis; hereditary spastic paraplegia 78; and primary pulmonary hypertension. Orthologous to several human genes including ATP13A3 (ATPase 13A3). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See YPK9 in Genome Data Viewer

Location:: chromosome: XV

Exon count:: 1

Sequence:: Chromosome: XV; NC_001147.6 (861175..865593)

Chromosome XV - NC_001147.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results suggest that Ypk9p may play a role in sequestration of divalent heavy metal ions.
Title: Cd2+, Mn2+, Ni2+ and Se2+ toxicity to Saccharomyces cerevisiae lacking YPK9p the orthologue of human ATP13A2.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent H2AZ histone chaperone activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent H3-H4 histone complex chaperone activity	IEA Inferred from Electronic Annotation more info
enables ATPase-coupled monoatomic cation transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATPase-coupled monoatomic cation transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables DNA clamp loader activity	IEA Inferred from Electronic Annotation more info
enables P-type ion transporter activity	IEA Inferred from Electronic Annotation more info
enables P-type ion transporter activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables chromatin extrusion motor activity	IEA Inferred from Electronic Annotation more info
enables cohesin loader activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chromatin looping	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in intracellular calcium ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in monoatomic cation transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
located_in fungal-type vacuole membrane	HDA more info	PubMed
located_in fungal-type vacuole membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in vacuolar membrane	IEA Inferred from Electronic Annotation more info
located_in vacuole	IEA Inferred from Electronic Annotation more info
located_in vacuole-mitochondrion membrane contact site	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: putative acid anhydride hydrolase

NP_014934.1

Vacuolar protein; involved in oxidative stress response and modulation of replicative lifespan; targeted to vacuole via AP-3 pathway; undergoes autophosphorylation, which is abolished by mutation of Asp781 in catalytic motif (D781N); P5 ATPase subfamily member with similarity to yeast Spf1p and homology to human ATP13A2 (PARK9), mutations in which are associated with Parkinson disease and Kufor-Rakeb syndrome

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001147.6 Reference assembly

Range

861175..865593

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183710.1 → NP_014934.1 TPA: putative acid anhydride hydrolase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014934.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W2Y9, Q12697

UniProtKB/TrEMBL

A6ZPC6, N1P3P0

Conserved Domains (1) summary

TIGR01657
Location:307 → 1431

P-ATPase-V; P-type ATPase of unknown pump specificity (type V)