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    SAM3 bifunctional polyamine/amino acid permease SAM3 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855854, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SAM3
    Official Full Name
    bifunctional polyamine/amino acid permease SAM3
    Primary source
    SGD:S000006195
    Locus tag
    YPL274W
    See related
    AllianceGenome:SGD:S000006195; FungiDB:YPL274W; VEuPathDB:YPL274W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables S-adenosyl-L-methionine transmembrane transporter activity; putrescine transmembrane transporter activity; and spermidine transmembrane transporter activity. Involved in S-adenosyl-L-methionine transport; putrescine transport; and spermidine transport. Located in plasma membrane. Human ortholog(s) of this gene implicated in retinitis pigmentosa 68. Orthologous to several human genes including SLC7A1 (solute carrier family 7 member 1); SLC7A14 (solute carrier family 7 member 14); and SLC7A2 (solute carrier family 7 member 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SAM3 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (22938..24701)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene pseudo Neighboring gene pseudo Neighboring gene S-adenosylmethionine-homocysteine S-methyltransferase SAM4 Neighboring gene Pbi1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transport of sulfonium compounds. Characterization of the s-adenosylmethionine and s-methylmethionine permeases from the yeast Saccharomyces cerevisiae. Rouillon A, et al. J Biol Chem, 1999 Oct 1. PMID 10497160
    2. Polyamine uptake by DUR3 and SAM3 in Saccharomyces cerevisiae. Uemura T, et al. J Biol Chem, 2007 Mar 9. PMID 17218313
    3. Homocysteine methyltransferases Mht1 and Sam4 prevent the accumulation of age-damaged (R,S)-AdoMet in the yeast Saccharomyces cerevisiae. Vinci CR, et al. J Biol Chem, 2010 Jul 2. PMID 20421295, Free PMC Article
    4. Complementation of the Yeast Model System Reveals that Caenorhabditis elegans OCT-1 Is a Functional Transporter of Anthracyclines. Brosseau N, et al. PLoS One, 2015. PMID 26177450, Free PMC Article
    5. Sinefungin resistance of Saccharomyces cerevisiae arising from Sam3 mutations that inactivate the AdoMet transporter or from increased expression of AdoMet synthase plus mRNA cap guanine-N7 methyltransferase. Zheng S, et al. Nucleic Acids Res, 2007. PMID 17932050, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables S-adenosyl-L-methionine transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables amino acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables putrescine transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables putrescine transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables spermidine transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables spermidine transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in S-adenosyl-L-methionine transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in S-adenosyl-L-methionine transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in amino acid transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in amino acid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in putrescine transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in putrescine transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermidine transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spermidine transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in spermidine transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    bifunctional polyamine/amino acid permease SAM3
    NP_015049.1
    • High-affinity S-adenosylmethionine permease; required for utilization of S-adenosylmethionine as a sulfur source; has similarity to S-methylmethionine permease Mmp1p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      22938..24701
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184088.1 → NP_015049.1  TPA: bifunctional polyamine/amino acid permease SAM3 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015049.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W396, Q08986, Q7LGU1
      UniProtKB/TrEMBL
      B3LML0, B5VSR5, C8ZIA5
      Conserved Domains (1) summary
      TIGR00913
      Location:74 → 551
      2A0310; amino acid permease (yeast)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08986.1

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