HYR1 peroxiredoxin HYR1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: HYR1
Official Full Name: peroxiredoxin HYR1
Primary source: SGD:S000001476
Locus tag: YIR037W
See related: AllianceGenome:SGD:S000001476; FungiDB:YIR037W; VEuPathDB:YIR037W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: GPX3; ORP1
Summary: Enables glutathione peroxidase activity and phospholipid-hydroperoxide glutathione peroxidase activity. Involved in cellular response to oxidative stress. Located in mitochondrial intermembrane space and peroxisomal matrix. Human ortholog(s) of this gene implicated in colorectal adenocarcinoma; colorectal cancer; and spondylometaphyseal dysplasia Sedaghatian type. Orthologous to human GPX4 (glutathione peroxidase 4). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See HYR1 in Genome Data Viewer

Location:: chromosome: IX

Exon count:: 1

Sequence:: Chromosome: IX; NC_001141.2 (423128..423619)

Chromosome IX - NC_001141.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001141.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Our data suggested that gpx3 is linked with maintenance of cellular phospholipids during Cd-induced oxidative stress. The results indicate that gpx3 might protect the phospholipids from Cd-induced oxidative damage in Saccharomyces cerevisiae.
Title: Glutathione peroxidase3 of Saccharomyces cerevisiae protects phospholipids during cadmium-induced oxidative stress.
glutathione peroxidase 3 protects GAPDH from NO stress and thereby contributes to the maintenance of homeostasis during exposure to NO stress
Title: The S-nitrosylation of glyceraldehyde-3-phosphate dehydrogenase 2 is reduced by interaction with glutathione peroxidase 3 in Saccharomyces cerevisiae.
Gpx3 interacts with Dak1, alleviates dihydroxyacetone-mediated stress by upregulating Dak activity, and consequently suppresses advanced glycation endproducts formation.
Title: Reduced formation of advanced glycation endproducts via interactions between glutathione peroxidase 3 and dihydroxyacetone kinase 1.
The crystal structure of Hyr1 from Saccharomyces cerevisiae, is reported.
Title: Crystal structure of glutathione-dependent phospholipid peroxidase Hyr1 from the yeast Saccharomyces cerevisiae.
Study identified 30 proteins that are related to the Gpx3-dependent oxidative stress responses and 17 proteins that are changed in a Gpx3-dependent manner regardless of oxidative stress.
Title: Gpx3-dependent responses against oxidative stress in Saccharomyces cerevisiae.
Molecular mechanism of oxidative stress perception by ORP1 is reported.
Title: Molecular mechanism of oxidative stress perception by the Orp1 protein.
Data suggested that Gpx3 protects GS from non-enzymatic proteolysis, thereby contributing to cell homeostasis when cell is exposed to oxidative stress.
Title: Glutathione peroxidase 3 of Saccharomyces cerevisiae suppresses non-enzymatic proteolysis of glutamine synthetase in an activity-independent manner.
phospholipid hydroperoxidase and Yap1-mediated signaling activities of Gpx3 have independent functional roles
Title: Genetic dissection of the phospholipid hydroperoxidase activity of yeast gpx3 reveals its functional importance.
Gpx3 functions as a redox-dependent exquisite regulator of the protein repair activity of methionine sulfoxide reductase Mxr1
Title: Glutathione peroxidase 3 of Saccharomyces cerevisiae regulates the activity of methionine sulfoxide reductase in a redox state-dependent way.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables glutathione peroxidase activity	IDA Inferred from Direct Assay more info	PubMed
enables glutathione peroxidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables peroxidase activity	IEA Inferred from Electronic Annotation more info
enables phospholipid-hydroperoxide glutathione peroxidase activity	IDA Inferred from Direct Assay more info	PubMed
enables phospholipid-hydroperoxide glutathione peroxidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables thioredoxin-dependent peroxiredoxin activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular oxidant detoxification	IEA Inferred from Electronic Annotation more info
involved_in cellular response to oxidative stress	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to oxidative stress	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	HDA more info	PubMed
located_in mitochondrial intermembrane space	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial intermembrane space	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in peroxisomal matrix	IDA Inferred from Direct Assay more info	PubMed
located_in peroxisomal matrix	IEA Inferred from Electronic Annotation more info
located_in peroxisome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: peroxiredoxin HYR1

NP_012303.1

EC 1.11.1.24

Glutathione peroxidase; functions as hydroperoxide receptor to sense intracellular hydroperoxide levels and transduce redox signal to Yap1p transcription factor; glutathione peroxidase activity is neuroprotective in models of Huntington's disease; HYR1 has a paralog, GPX1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001141.2 Reference assembly

Range

423128..423619

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179559.1 → NP_012303.1 TPA: peroxiredoxin HYR1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012303.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VVW8, P40581

UniProtKB/TrEMBL

A6ZVV7, B3LTH3, B5VKX4, C7GLR9, C8ZAU0, G2WFW5, N1P1U2

Conserved Domains (1) summary

COG0386
Location:1 → 161

BtuE; Glutathione peroxidase, house-cleaning role in reducing lipid peroxides [Defense mechanisms, Lipid transport and metabolism]