GPP1 glycerol-1-phosphatase GPP1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: GPP1
Official Full Name: glycerol-1-phosphatase GPP1
Primary source: SGD:S000001315
Locus tag: YIL053W
See related: AllianceGenome:SGD:S000001315; FungiDB:YIL053W; VEuPathDB:YIL053W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: RHR2
Summary: Enables glycerol-1-phosphatase activity. Involved in glycerol biosynthetic process. Located in cytoplasm. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See GPP1 in Genome Data Viewer

Location:: chromosome: IX

Exon count:: 1

Sequence:: Chromosome: IX; NC_001141.2 (255115..255867)

Chromosome IX - NC_001141.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001141.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study found that the gpp1gpp2 strain is hypersensitive to cell wall stress such as treatment with beta-1,3-glucanase containing cocktail Zymolyase and chitin-binding dye Calcofluor-white.
Title: Thermosensitivity of the Saccharomyces cerevisiae gpp1gpp2 double deletion strain can be reduced by overexpression of genes involved in cell wall maintenance.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables glycerol-1-phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glycerol-1-phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables glycerol-1-phosphatase activity	IEA Inferred from Electronic Annotation more info
enables glycerol-3-phosphatase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phosphatase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in glycerol biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycerol biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to osmotic stress	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to osmotic stress	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	HDA more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: glycerol-1-phosphatase GPP1

NP_012211.2

EC 3.1.3.21

Constitutively expressed DL-glycerol-3-phosphate phosphatase; also known as glycerol-1-phosphatase; involved in glycerol biosynthesis, induced in response to both anaerobic and osmotic stress; GPP1 has a paralog, GPP2, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001141.2 Reference assembly

Range

255115..255867

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179403.1 → NP_012211.2 TPA: glycerol-1-phosphatase GPP1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012211.2

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VVM8, P38012, P41277

UniProtKB/TrEMBL

C7GVY1, C8ZAJ3, G2WG92, N1P256

Conserved Domains (1) summary

cd07527
Location:14 → 227

HAD_ScGPP-like; subfamily of beta-phosphoglucomutase-like family, similar to Saccharomyces cerevisiae DL-glycerol-3-phosphate phosphatase (GPP1p/ Rhr2p and GPP2p/HOR2p) and 2-deoxyglucose-6-phosphate phosphatase (DOG1p and DOG2p)