TRM5 tRNA (guanine) methyltransferase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: TRM5
Official Full Name: tRNA (guanine) methyltransferase
Primary source: SGD:S000001112
Locus tag: YHR070W
See related: AllianceGenome:SGD:S000001112; FungiDB:YHR070W; VEuPathDB:YHR070W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables tRNA (guanine(37)-N1)-methyltransferase activity. Involved in mitochondrial tRNA methylation and tRNA N1-guanine methylation. Located in mitochondrial matrix. Used to study several diseases, including hypercalcemia; hypertrophic cardiomyopathy; lactic acidosis; mitochondrial complex III deficiency; and mitochondrial myopathy. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 26. Orthologous to human TRMT5 (tRNA methyltransferase 5). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See TRM5 in Genome Data Viewer

Location:: chromosome: VIII

Exon count:: 1

Sequence:: Chromosome: VIII; NC_001140.6 (234881..236380)

Chromosome VIII - NC_001140.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

mitochondrial initiator tRNA is methylated at guanosine 37 by the Trm5-encoded tRNA (guanine-N1-)-methyltransferase
Title: Yeast mitochondrial initiator tRNA is methylated at guanosine 37 by the Trm5-encoded tRNA (guanine-N1-)-methyltransferase.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables tRNA (guanine(37)-N1)-methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables tRNA (guanine(37)-N1)-methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables tRNA (guanine(37)-N1)-methyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables tRNA methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in methylation	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial tRNA methylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial tRNA methylation	IDA Inferred from Direct Assay more info	PubMed
involved_in tRNA N1-guanine methylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in tRNA N1-guanine methylation	IDA Inferred from Direct Assay more info	PubMed
involved_in tRNA N1-guanine methylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tRNA methylation	IEA Inferred from Electronic Annotation more info
involved_in tRNA processing	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrial matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial matrix	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in nucleus	HDA more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: tRNA (guanine) methyltransferase

NP_011937.1

EC 2.1.1.228

tRNA(m(1)G37)methyltransferase; methylates a tRNA base adjacent to the anticodon that has a role in prevention of frameshifting; localized to both cytoplasm and mitochondria, and modifies both cytoplasmic and mitochondrial tRNAs; mutations in human ortholog TRMT5 are associated with skeletal muscle respiratory chain deficiencies, and trm5 mutations analogous to disease mutations decrease respiration

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001140.6 Reference assembly

Range

234881..236380

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179200.1 → NP_011937.1 TPA: tRNA (guanine) methyltransferase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_011937.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D3DL19, P38793

UniProtKB/TrEMBL

A6ZSX6, B3LSI8, C7GWT1, C8Z9K9, G2WFE2

Conserved Domains (1) summary

COG2520
Location:75 → 459

Trm5; tRNA G37 N-methylase Trm5 [Translation, ribosomal structure and biogenesis]