U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    ERC1 Erc1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856427, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    ERC1
    Official Full Name
    Erc1p
    Primary source
    SGD:S000001074
    Locus tag
    YHR032W
    See related
    AllianceGenome:SGD:S000001074; FungiDB:YHR032W; VEuPathDB:YHR032W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable transmembrane transporter activity. Involved in S-adenosylmethionine biosynthetic process. Predicted to be active in membrane. Orthologous to human SLC47A1 (solute carrier family 47 member 1) and SLC47A2 (solute carrier family 47 member 2). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See ERC1 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (173344..175089)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene mitogen-activated serine/threonine-protein kinase SLT2 Neighboring gene DNA helicase Neighboring gene putative glutamate 5-kinase Neighboring gene Pih1p

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Production of S-adenosyl-L-methionine by Saccharomyces cerevisiae cells carrying a gene for ethionine resistance. Shiomi N, et al. Biotechnol Bioeng, 1990 May. PMID 18592490
    2. Sake yeast YHR032W/ERC1 haplotype contributes to high S-adenosylmethionine accumulation in sake yeast strains. Kanai M, et al. J Biosci Bioeng, 2017 Jan. PMID 27567046
    3. Genetic basis of metabolome variation in yeast. Breunig JS, et al. PLoS Genet, 2014 Mar. PMID 24603560, Free PMC Article
    4. Stimulating S-adenosyl-l-methionine synthesis extends lifespan via activation of AMPK. Ogawa T, et al. Proc Natl Acad Sci U S A, 2016 Oct 18. PMID 27698120, Free PMC Article
    5. An evolutionary proteomics approach identifies substrates of the cAMP-dependent protein kinase. Budovskaya YV, et al. Proc Natl Acad Sci U S A, 2005 Sep 27. PMID 16172400, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables xenobiotic transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in S-adenosylmethionine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in xenobiotic detoxification by transmembrane export across the plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Erc1p
    NP_011897.1
    • Member of the multi-drug and toxin extrusion (MATE) family; the MATE family is part of the multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) exporter superfamily; overproduction confers ethionine resistance and accumulation of S-adenosylmethionine

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      173344..175089
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179162.1 → NP_011897.1  TPA: Erc1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011897.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DKX9, P38767
      UniProtKB/TrEMBL
      C8ZAA1, N1P558
      Conserved Domains (1) summary
      cd13132
      Location:164 → 544
      MATE_eukaryotic; Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38767.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous