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    VSB1 Vsb1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853026, updated on 9-Dec-2024

    Summary

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    Official Symbol
    VSB1
    Official Full Name
    Vsb1p
    Primary source
    SGD:S000003357
    Locus tag
    YGR125W
    See related
    AllianceGenome:SGD:S000003357; FungiDB:YGR125W; VEuPathDB:YGR125W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables arginine binding activity. Acts upstream of or within basic amino acid transmembrane import into vacuole. Located in fungal-type vacuole. Is active in fungal-type vacuole membrane. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See VSB1 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (742325..745435)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene tRNA-Ile Neighboring gene asparagine synthase (glutamine-hydrolyzing) 2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ygr125w/Vsb1-dependent accumulation of basic amino acids into vacuoles of Saccharomyces cerevisiae. Kawano-Kawada M, et al. Biosci Biotechnol Biochem, 2021 Apr 24. PMID 33704406
    2. Nitrogen coordinated import and export of arginine across the yeast vacuolar membrane. Cools M, et al. PLoS Genet, 2020 Aug. PMID 32776922, Free PMC Article
    3. Insights into TOR function and rapamycin response: chemical genomic profiling by using a high-density cell array method. Xie MW, et al. Proc Natl Acad Sci U S A, 2005 May 17. PMID 15883373, Free PMC Article
    4. The yeast vacuolar membrane proteome. Wiederhold E, et al. Mol Cell Proteomics, 2009 Feb. PMID 19001347
    5. Characterization of the rapamycin-sensitive phosphoproteome reveals that Sch9 is a central coordinator of protein synthesis. Huber A, et al. Genes Dev, 2009 Aug 15. PMID 19684113, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ygr125w/Vsb1-dependent accumulation of basic amino acids into vacuoles of Saccharomyces cerevisiae.
      Title: Ygr125w/Vsb1-dependent accumulation of basic amino acids into vacuoles of Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables arginine binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in amino acid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within basic amino acid transmembrane import into vacuole IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in basic amino acid transmembrane import into vacuole IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in fungal-type vacuole HDA PubMed 
    is_active_in fungal-type vacuole membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in fungal-type vacuole membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in vacuolar membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Vsb1p
    NP_011641.1
    • Vacuolar membrane protein required for uptake and storage of arginine in nitrogen-replete cells; nitrogen starvation appears to inhibit Vsb1-dependent activity, resulting in mobilization of stored vacuolar arginine to the cytosol; arginine uptake appears to be driven by a V-ATPase mediated H+ gradient; member of the APC (amino acid-polyamine-organocation) transporter superfamily

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      742325..745435
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181254.1 → NP_011641.1  TPA: Vsb1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011641.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VUQ7, P53273
      UniProtKB/TrEMBL
      A6ZUD9, B3LIA3, B5VJ71, C7GUH0, C8Z918
      Conserved Domains (2) summary
      COG0659
      Location:128 → 785
      SUL1; Sulfate permease or related transporter, MFS superfamily [Inorganic ion transport and metabolism]
      cd00038
      Location:910 → 1014
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53273.1

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