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    AIM14 putative metalloreductase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852716, updated on 9-Dec-2024

    Summary

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    Official Symbol
    AIM14
    Official Full Name
    putative metalloreductase
    Primary source
    SGD:S000003128
    Locus tag
    YGL160W
    See related
    AllianceGenome:SGD:S000003128; FungiDB:YGL160W; VEuPathDB:YGL160W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    YNO1
    Summary
    Enables superoxide-generating NAD(P)H oxidase activity. Involved in apoptotic process and regulation of actin cytoskeleton organization. Located in perinuclear endoplasmic reticulum. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See AIM14 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (200561..202273)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Sut1p Neighboring gene Yip5p Neighboring gene uncharacterized protein Neighboring gene tRNA-Leu

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Fungal NOX is an essential factor for induction of TG2 in human hepatocytes. Huang Y, et al. Med Mycol, 2020 Jul 1. PMID 31642483
    2. Intramembrane bis-heme motif for transmembrane electron transport conserved in a yeast iron reductase and the human NADPH oxidase. Finegold AA, et al. J Biol Chem, 1996 Dec 6. PMID 8940093
    3. Saccharomyces cerevisiae strains as bioindicators for titanium dioxide sunscreen photoprotective and photomutagenic assessment. Diniz RR, et al. J Photochem Photobiol B, 2019 Sep. PMID 31434036
    4. Yno1p/Aim14p, a NADPH-oxidase ortholog, controls extramitochondrial reactive oxygen species generation, apoptosis, and actin cable formation in yeast. Rinnerthaler M, et al. Proc Natl Acad Sci U S A, 2012 May 29. PMID 22586098, Free PMC Article
    5. Mitochondrial dysfunction reduces yeast replicative lifespan by elevating RAS-dependent ROS production by the ER-localized NADPH oxidase Yno1. Yi DG, et al. PLoS One, 2018. PMID 29912878, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that YGL160W (AIM14) encodes a genuine NADPH oxidase, which is located in the endoplasmic reticulum (ER) and produces superoxide in a NADPH-dependent fashion, and renamed it YNO1 (yeast NADPH oxidase 1).
      Title: Yno1p/Aim14p, a NADPH-oxidase ortholog, controls extramitochondrial reactive oxygen species generation, apoptosis, and actin cable formation in yeast.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ferric-chelate reductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables superoxide-generating NAD(P)H oxidase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in reductive iron assimilation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perinuclear endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    putative metalloreductase
    NP_011355.1
    • NADPH oxidase localized to the perinuclear ER; produces superoxide from NADPH; overexpression causes MCA1 dependent apoptosis; likely involved in superoxide-mediated regulation of the actin cytoskeleton; member of a conserved superfamily of NADPH oxidases (NOX enzymes); has similarity to iron/copper reductases (FRE1-8), particularly Fre8p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      200561..202273
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181025.1 → NP_011355.1  TPA: putative metalloreductase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011355.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A6ZU25, D6VTZ1, P53109
      UniProtKB/TrEMBL
      N1P4D3
      Conserved Domains (3) summary
      pfam08022
      Location:253 → 365
      FAD_binding_8; FAD-binding domain
      pfam08030
      Location:372 → 557
      NAD_binding_6; Ferric reductase NAD binding domain
      pfam01794
      Location:104 → 219
      Ferric_reduct; Ferric reductase like transmembrane component
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53109.1

    Gene LinkOut

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