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    NCS6 Ncs6p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852661, updated on 9-Dec-2024

    Summary

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    Official Symbol
    NCS6
    Official Full Name
    Ncs6p
    Primary source
    SGD:S000003179
    Locus tag
    YGL211W
    See related
    AllianceGenome:SGD:S000003179; FungiDB:YGL211W; VEuPathDB:YGL211W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    TUC1; YGL210W-A
    Summary
    Enables tRNA binding activity. Involved in protein urmylation and tRNA wobble position uridine thiolation. Located in cytosol and peroxisome. Orthologous to human CTU1 (cytosolic thiouridylase subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See NCS6 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (92512..93591)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene SKI complex subunit WD repeat protein SKI8 Neighboring gene Vam7p Neighboring gene Rab family GTPase YPT32 Neighboring gene Mig2p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The role of wobble uridine modifications in +1 translational frameshifting in eukaryotes. Tükenmez H, et al. Nucleic Acids Res, 2015 Oct 30. PMID 26283182, Free PMC Article
    2. Global translational impacts of the loss of the tRNA modification t(6)A in yeast. Thiaville PC, et al. Microb Cell, 2016 Jan 1. PMID 26798630, Free PMC Article
    3. tRNA thiolation links translation to stress responses in Saccharomyces cerevisiae. Damon JR, et al. Mol Biol Cell, 2015 Jan 15. PMID 25392298, Free PMC Article
    4. Deciphering the reading of the genetic code by near-cognate tRNA. Blanchet S, et al. Proc Natl Acad Sci U S A, 2018 Mar 20. PMID 29507244, Free PMC Article
    5. Elongator-dependent modification of cytoplasmic tRNALysUUU is required for mitochondrial function under stress conditions. Tigano M, et al. Nucleic Acids Res, 2015 Sep 30. PMID 26240381, Free PMC Article

    See all (67) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables tRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein urmylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein urmylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA thio-modification IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA wobble position uridine thiolation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA wobble position uridine thiolation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tRNA wobble uridine modification IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA wobble uridine modification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of cytosolic tRNA wobble base thiouridylase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Ncs6p
    NP_011304.2
    • Protein required for uridine thiolation of Gln, Lys, and Glu tRNAs; required for the thiolation of uridine at the wobble position of Gln, Lys, and Glu tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae; localizes to cytosol and peroxisomes

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      92512..93591
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181076.1 → NP_011304.2  TPA: Ncs6p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011304.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A6ZTX8, B3LHQ7, D6VTU4, P53088, Q92322
      UniProtKB/TrEMBL
      C8Z844, G2WDP7, N1P9Z5
      Conserved Domains (2) summary
      cd01993
      Location:69 → 256
      Alpha_ANH_like_II; This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily ...
      cl25646
      Location:220 → 329
      zn-ribbon_14; Zinc-ribbon
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53088.3

    Gene LinkOut

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