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    OST5 dolichyl-diphosphooligosaccharide--protein glycotransferase subunit [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852625, updated on 9-Dec-2024

    Summary

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    Official Symbol
    OST5
    Official Full Name
    dolichyl-diphosphooligosaccharide--protein glycotransferase subunit
    Primary source
    SGD:S000003194
    Locus tag
    YGL226C-A
    See related
    AllianceGenome:SGD:S000003194; FungiDB:YGL226C-A; VEuPathDB:YGL226C-A
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables structural molecule activity. Involved in protein N-linked glycosylation. Part of oligosaccharyltransferase complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See OST5 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    2
    Sequence:
    Chromosome: VII; NC_001139.9 (72749..73158, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene She10p Neighboring gene glucose-induced degradation complex subunit VID30 Neighboring gene tRNA-Val Neighboring gene Mtc3p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Saccharomyces cerevisiae oligosaccharyltransferase is a protein complex composed of Wbp1p, Swp1p, and four additional polypeptides. Kelleher DJ, et al. J Biol Chem, 1994 Apr 29. PMID 8175708
    2. Studies of yeast oligosaccharyl transferase subunits using the split-ubiquitin system: topological features and in vivo interactions. Yan A, et al. Proc Natl Acad Sci U S A, 2005 May 17. PMID 15886282, Free PMC Article
    3. The oligosaccharyltransferase complex from Saccharomyces cerevisiae. Isolation of the OST6 gene, its synthetic interaction with OST3, and analysis of the native complex. Knauer R, et al. J Biol Chem, 1999 Jun 11. PMID 10358084
    4. The highly conserved Stt3 protein is a subunit of the yeast oligosaccharyltransferase and forms a subcomplex with Ost3p and Ost4p. Karaoglu D, et al. J Biol Chem, 1997 Dec 19. PMID 9405463
    5. The atomic structure of a eukaryotic oligosaccharyltransferase complex. Bai L, et al. Nature, 2018 Mar 15. PMID 29466327, Free PMC Article

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables structural molecule activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein N-linked glycosylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein N-linked glycosylation IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of oligosaccharyltransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of oligosaccharyltransferase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of oligosaccharyltransferase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dolichyl-diphosphooligosaccharide--protein glycotransferase subunit
    NP_011288.1
    • Zeta subunit of the oligosaccharyltransferase complex of the ER lumen; complex catalyzes asparagine-linked glycosylation of newly synthesized proteins

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      72749..73158 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181091.1 → NP_011288.1  TPA: dolichyl-diphosphooligosaccharide--protein glycotransferase subunit [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011288.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VVA8, P87030, Q92316
      UniProtKB/TrEMBL
      A6ZTW4, B3LHR9, C8Z828, G2WDN3, N1P5W7
      Conserved Domains (1) summary
      pfam05251
      Location:14 → 86
      Ost5; Oligosaccharyltransferase subunit 5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q92316.2

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