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    CDC14 phosphoprotein phosphatase CDC14 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850585, updated on 9-Dec-2024

    Summary

    Official Symbol
    CDC14
    Official Full Name
    phosphoprotein phosphatase CDC14
    Primary source
    SGD:S000001924
    Locus tag
    YFR028C
    See related
    AllianceGenome:SGD:S000001924; FungiDB:YFR028C; VEuPathDB:YFR028C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    OAF3
    Summary
    Enables protein serine/threonine phosphatase activity. Involved in several processes, including meiotic spindle disassembly; positive regulation of organelle organization; and rDNA chromatin condensation. Located in several cellular components, including cellular bud neck; new mitotic spindle pole body; and nucleus. Part of RENT complex. Is active in nucleolus. Used to study autosomal recessive nonsyndromic deafness 32; colorectal carcinoma; and vascular disease. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 32. Orthologous to human CDC14A (cell division cycle 14A); CDC14B (cell division cycle 14B); and CDC14C (cell division cycle 14C). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See CDC14 in Genome Data Viewer
    Location:
    chromosome: VI
    Exon count:
    1
    Sequence:
    Chromosome: VI; NC_001138.5 (208413..210068, complement)

    Chromosome VI - NC_001138.5Genomic Context describing neighboring genes Neighboring gene Uli1p Neighboring gene Eco1p Neighboring gene tRNA-Tyr Neighboring gene Ptr3p

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by SGD

    Process Evidence Code Pubs
    involved_in autophagy of mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to osmotic stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in meiotic nuclear division IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in meiotic spindle disassembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase I IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of autophagosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of autophagy IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of mitotic actomyosin contractile ring assembly IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of mitotic actomyosin contractile ring assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in rDNA chromatin condensation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of exit from mitosis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of exit from mitosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of RENT complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cellular bud neck IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cellular bud neck IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoplasm IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in intracellular membraneless organelle IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in mitotic spindle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitotic spindle pole body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in new mitotic spindle pole body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in spindle pole IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in spindle pole body IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in spindle pole body IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    phosphoprotein phosphatase CDC14
    NP_116684.3
    • Protein phosphatase required for mitotic exit; required for rDNA segregation, cytokinesis, meiosis I spindle disassembly, environmental stress response, autophagy during meiosis; downregulates microautophagy induction after TORC1 inactivation; held in nucleolus by Cdc55p in early meiosis, liberated by FEAR and Mitotic Exit Network in anaphase; sequestered in metaphase II, released upon entry into anaphase II; human homolog CDC14A can complement thermosensitivity of cdc14-1 mutant

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001138.5 Reference assembly

      Range
      208413..210068 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179993.3NP_116684.3  TPA: phosphoprotein phosphatase CDC14 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_116684.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VTQ8, Q00684, Q05180, Q05673
      UniProtKB/TrEMBL
      A7A265, C7GYD2, C8Z7W3, G2WDG6, N1P4Q7
      Conserved Domains (3) summary
      PRK08581
      Location:403513
      PRK08581; amidase domain-containing protein
      cd14499
      Location:161340
      CDC14_C; C-terminal dual-specificity phosphatase domain of CDC14 family proteins
      pfam14671
      Location:14151
      DSPn; Dual specificity protein phosphatase, N-terminal half