U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    SMB1 mRNA splicing protein SMB1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856751, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    SMB1
    Official Full Name
    mRNA splicing protein SMB1
    Primary source
    SGD:S000000831
    Locus tag
    YER029C
    See related
    AllianceGenome:SGD:S000000831; FungiDB:YER029C; VEuPathDB:YER029C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable snRNP binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Part of U2-type prespliceosome and spliceosomal snRNP complex. Human ortholog(s) of this gene implicated in Prader-Willi syndrome; cerebrocostomandibular syndrome; and mixed connective tissue disease. Orthologous to human SNURF (SNRPN upstream open reading frame); SNRPN (small nuclear ribonucleoprotein polypeptide N); and SNRPB (small nuclear ribonucleoprotein polypeptides B and B1). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See SMB1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    1
    Sequence:
    Chromosome: V; NC_001137.3 (212587..213177, complement)

    Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene Gal83p Neighboring gene Mig3p Neighboring gene Chz1p Neighboring gene Rab family GTPase YPT31

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_001137.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. A biochemical function for the Sm complex. Zhang D, et al. Mol Cell, 2001 Feb. PMID 11239461
    2. Hypermethylation of the cap structure of both yeast snRNAs and snoRNAs requires a conserved methyltransferase that is localized to the nucleolus. Mouaikel J, et al. Mol Cell, 2002 Apr. PMID 11983179
    3. Functional characterization of nuclear localization signals in yeast Sm proteins. Bordonné R. Mol Cell Biol, 2000 Nov. PMID 11027265, Free PMC Article
    4. Stoichiometry of the Sm proteins in yeast spliceosomal snRNPs supports the heptamer ring model of the core domain. Walke S, et al. J Mol Biol, 2001 Apr 20. PMID 11302706
    5. Nuclear Pre-snRNA Export Is an Essential Quality Assurance Mechanism for Functional Spliceosomes. Becker D, et al. Cell Rep, 2019 Jun 11. PMID 31189105

    See all (77) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables snRNP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA splicing, via spliceosome ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of U1 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U1 snRNP IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of U2 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U2-type prespliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U2-type prespliceosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of U4 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U4/U6 x U5 tri-snRNP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U4/U6 x U5 tri-snRNP complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of U5 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U5 snRNP IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of catalytic step 2 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    mRNA splicing protein SMB1
    NP_010946.3
    • Core Sm protein Sm B; part of heteroheptameric complex (with Smd1p, Smd2p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm B and Sm B'

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001137.3 Reference assembly

      Range
      212587..213177 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178920.3 → NP_010946.3  TPA: mRNA splicing protein SMB1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010946.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DLS8, P40018
      UniProtKB/TrEMBL
      A6ZQX8, B3LS42, B5VHG4, C7GSH6, C8Z731, G2WCR2, N1P528
      Conserved Domains (1) summary
      cd01717
      Location:8 → 98
      Sm_B; Sm protein B
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40018.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools