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    GLC3 1,4-alpha-glucan branching enzyme [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856705, updated on 9-Dec-2024

    Summary

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    Official Symbol
    GLC3
    Official Full Name
    1,4-alpha-glucan branching enzyme
    Primary source
    SGD:S000000737
    Locus tag
    YEL011W
    See related
    AllianceGenome:SGD:S000000737; FungiDB:YEL011W; VEuPathDB:YEL011W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    GHA1
    Summary
    Enables 1,4-alpha-glucan branching enzyme activity. Involved in glycogen biosynthetic process. Located in cytoplasm. Used to study glycogen storage disease IV. Human ortholog(s) of this gene implicated in glycogen storage disease IV and pulmonary tuberculosis. Orthologous to human GBE1 (1,4-alpha-glucan branching enzyme 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See GLC3 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    1
    Sequence:
    Chromosome: V; NC_001137.3 (133120..135234)

    Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene tRNA-Gln Neighboring gene E2 ubiquitin-conjugating protein UBC8 Neighboring gene tRNA-Lys Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001137.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Coordinate regulation of glycogen metabolism in the yeast Saccharomyces cerevisiae. Induction of glycogen branching enzyme. Thon VJ, et al. J Biol Chem, 1992 Jul 25. PMID 1634552
    2. GLC3 and GHA1 of Saccharomyces cerevisiae are allelic and encode the glycogen branching enzyme. Rowen DW, et al. Mol Cell Biol, 1992 Jan. PMID 1729600, Free PMC Article
    3. Trehalose is a key determinant of the quiescent metabolic state that fuels cell cycle progression upon return to growth. Shi L, et al. Mol Biol Cell, 2010 Jun 15. PMID 20427572, Free PMC Article
    4. Isolation of human glycogen branching enzyme cDNAs by screening complementation in yeast. Thon VJ, et al. J Biol Chem, 1993 Apr 5. PMID 8463281
    5. Cellular Control of Viscosity Counters Changes in Temperature and Energy Availability. Persson LB, et al. Cell, 2020 Dec 10. PMID 33157040, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables 1,4-alpha-glucan branching enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 1,4-alpha-glucan branching enzyme activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 1,4-alpha-glucan branching enzyme activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables cation binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, hydrolyzing O-glycosyl compounds IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycogen biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycogen biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycogen biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    1,4-alpha-glucan branching enzyme
    NP_010905.1
    • Glycogen branching enzyme, involved in glycogen accumulation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress; glycogen accumulation defect of the null mutant is functionally complemented by human GBE1, which is associated with glycogen storage disease

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001137.3 Reference assembly

      Range
      133120..135234
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178826.1 → NP_010905.1  TPA: 1,4-alpha-glucan branching enzyme [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010905.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DLN8, P32775
      UniProtKB/TrEMBL
      A6ZQT8, B3LS05, C8Z6Y9, G2WCM1, N1P5D9
      Conserved Domains (1) summary
      PLN02447
      Location:9 → 702
      PLN02447; 1,4-alpha-glucan-branching enzyme
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32775.2

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