SYF1 mRNA splicing protein SYF1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: SYF1
Official Full Name: mRNA splicing protein SYF1
Primary source: SGD:S000002824
Locus tag: YDR416W
See related: AllianceGenome:SGD:S000002824; FungiDB:YDR416W; VEuPathDB:YDR416W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: NTC90
Summary: Predicted to contribute to first spliceosomal transesterification activity and second spliceosomal transesterification activity. Involved in generation of catalytic spliceosome for first transesterification step. Located in cytosol and nucleus. Part of Prp19 complex and U2-type spliceosomal complex. Orthologous to human XAB2 (XPA binding protein 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See SYF1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 1

Sequence:: Chromosome: IV; NC_001136.10 (1298432..1301011)

Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A novel role of the NTC in recruiting splicing factors to the spliceosome after its activation.
Title: Ntc90 is required for recruiting first step factor Yju2 but not for spliceosome activation.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
contributes_to first spliceosomal transesterification activity	IC Inferred by Curator more info	PubMed
contributes_to second spliceosomal transesterification activity	IC Inferred by Curator more info	PubMed

Process	Evidence Code	Pubs
involved_in RNA processing	IEA Inferred from Electronic Annotation more info
involved_in RNA splicing	IEA Inferred from Electronic Annotation more info
involved_in generation of catalytic spliceosome for first transesterification step	IBA Inferred from Biological aspect of Ancestor more info
involved_in generation of catalytic spliceosome for first transesterification step	IDA Inferred from Direct Assay more info	PubMed
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA splicing, via spliceosome	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of Prp19 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Prp19 complex	IDA Inferred from Direct Assay more info	PubMed
part_of U2-type catalytic step 1 spliceosome	IDA Inferred from Direct Assay more info	PubMed
part_of U2-type catalytic step 2 spliceosome	IBA Inferred from Biological aspect of Ancestor more info
part_of U2-type catalytic step 2 spliceosome	IDA Inferred from Direct Assay more info	PubMed
part_of U2-type post-mRNA release spliceosomal complex	IDA Inferred from Direct Assay more info	PubMed
part_of U2-type prespliceosome	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of post-mRNA release spliceosomal complex	IBA Inferred from Biological aspect of Ancestor more info
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info
part_of spliceosomal complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: mRNA splicing protein SYF1

NP_010704.1

Member of the NineTeen Complex (NTC); that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; null mutant has splicing defect and arrests in G2/M; relocalizes to the cytosol in response to hypoxia; homologs in human and C. elegans

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001136.10 Reference assembly

Range

1298432..1301011

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180724.1 → NP_010704.1 TPA: mRNA splicing protein SYF1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010704.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VT47, Q04048

UniProtKB/TrEMBL

B3LFN9, C7GSB3, N1P8V6

Conserved Domains (1) summary

COG5107
Location:16 → 102

RNA14; Pre-mRNA 3'-end processing (cleavage and polyadenylation) factor [RNA processing and modification]