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    PDC2 Pdc2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851654, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PDC2
    Official Full Name
    Pdc2p
    Primary source
    SGD:S000002488
    Locus tag
    YDR081C
    See related
    AllianceGenome:SGD:S000002488; FungiDB:YDR081C; VEuPathDB:YDR081C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of glycolytic fermentation to ethanol; positive regulation of thiamine biosynthetic process; and positive regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in inner ear disease and primary biliary cholangitis. Orthologous to several human genes including TIGD4 (tigger transposable element derived 4). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See PDC2 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (607304..610081, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene TFIIH complex subunit TFB5 Neighboring gene Vps41p Neighboring gene Stn1p Neighboring gene 25S rRNA (adenine645-N1)-methyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterisation of PDC2, a gene necessary for high level expression of pyruvate decarboxylase structural genes in Saccharomyces cerevisiae. Hohmann S. Mol Gen Genet, 1993 Dec. PMID 8264540
    2. Construction of low-ethanol-wine yeasts through partial deletion of the Saccharomyces cerevisiae PDC2 gene. Cuello RA, et al. AMB Express, 2017 Dec. PMID 28324615, Free PMC Article
    3. Pyruvate decarboxylase and thiamine biosynthetic genes are regulated differently by Pdc2 in S. cerevisiae and C. glabrata. Iosue CL, et al. PLoS One, 2023. PMID 37285346, Free PMC Article
    4. Suppression of pdc2 regulating pyruvate decarboxylase synthesis in yeast. Velmurugan S, et al. Genetics, 1997 Mar. PMID 9055069, Free PMC Article
    5. Thiamin-dependent transactivation activity of PDC2 in Saccharomyces cerevisiae. Nosaka K, et al. FEBS Lett, 2008 Dec 10. PMID 19013460

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Pyruvate decarboxylase and thiamine biosynthetic genes are regulated differently by Pdc2 in S. cerevisiae and C. glabrata.
      Title: Pyruvate decarboxylase and thiamine biosynthetic genes are regulated differently by Pdc2 in S. cerevisiae and C. glabrata.
    2. Thi3p causes a conformational change in Pdc2p leading to full transactivation activity under favorable conditions.
      Title: Thiamin-dependent transactivation activity of PDC2 in Saccharomyces cerevisiae.
    3. Pdc2 is required for the upregulation of all genes controlled by thiamine availability
      Title: Pdc2 coordinates expression of the THI regulon in the yeast Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of glycolytic fermentation to ethanol IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of thiamine biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of thiamine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IC
    Inferred by Curator
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Pdc2p
    NP_010366.1
    • Transcription factor for thiamine-regulated genes; required for expression of the two isoforms of pyruvate decarboxylase (PDC1 and PDC5) along with thiamine biosynthetic genes; binds a DNA sequence in the PDC5 promoter; mutant fails to grow on 2% glucose and thus is scored as inviable under standard conditions

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      607304..610081 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180389.1 → NP_010366.1  TPA: Pdc2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010366.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VS68, E9PAG9, P32896
      UniProtKB/TrEMBL
      A6ZY47, B5VFX7, C7GVQ5, N1PAC9
      Conserved Domains (3) summary
      PLN02217
      Location:716 → 829
      PLN02217; probable pectinesterase/pectinesterase inhibitor
      pfam03184
      Location:198 → 406
      DDE_1; DDE superfamily endonuclease
      pfam03221
      Location:72 → 135
      HTH_Tnp_Tc5; Tc5 transposase DNA-binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32896.2

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