ATG15 triglyceride lipase ATG15 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: ATG15
Official Full Name: triglyceride lipase ATG15
Primary source: SGD:S000000664
Locus tag: YCR068W
See related: AllianceGenome:SGD:S000000664; FungiDB:YCR068W; VEuPathDB:YCR068W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: AUT5; CVT17
Summary: Enables phospholipase activity. Involved in several processes, including cellular lipid catabolic process; macroautophagy; and multivesicular body membrane disassembly. Located in membrane and vacuolar lumen. Is active in endoplasmic reticulum and vacuolar membrane. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ATG15 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 1

Sequence:: Chromosome: III; NC_001135.5 (237214..238776)

Chromosome III - NC_001135.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001135.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Topology and Function of the S. cerevisiae Autophagy Protein Atg15.
Title: Topology and Function of the S. cerevisiae Autophagy Protein Atg15.
Atg15 in Saccharomyces cerevisiae consists of two functionally distinct domains.
Title: Atg15 in Saccharomyces cerevisiae consists of two functionally distinct domains.
ATG15 encodes a phospholipase that preferentially hydrolyzes phosphatidylserine. ATG15 promoter binds Yap1p.
Title: ATG15 encodes a phospholipase and is transcriptionally regulated by YAP1 in Saccharomyces cerevisiae.
vacuolar putative lipase Atg15 accelerates degradation of lipid droplets through lipolysis
Title: A defect of the vacuolar putative lipase Atg15 accelerates degradation of lipid droplets through lipolysis.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables phospholipase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phospholipase activity	IDA Inferred from Direct Assay more info	PubMed
enables phospholipase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables triacylglycerol lipase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in autophagy	IDA Inferred from Direct Assay more info	PubMed
involved_in autophagy	IEA Inferred from Electronic Annotation more info
involved_in autophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipid catabolic process	IEA Inferred from Electronic Annotation more info
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in membrane disassembly	IDA Inferred from Direct Assay more info	PubMed
involved_in membrane disassembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in multivesicular body membrane disassembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in multivesicular body membrane disassembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neutral lipid catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in neutral lipid catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pexophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphatidylserine catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylserine catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in phosphatidylserine catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in piecemeal microautophagy of the nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in piecemeal microautophagy of the nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vacuolar protein processing	IDA Inferred from Direct Assay more info	PubMed
involved_in vacuolar protein processing	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	HDA more info	PubMed
is_active_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endosome	IEA Inferred from Electronic Annotation more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in multivesicular body membrane	IEA Inferred from Electronic Annotation more info
is_active_in vacuolar lumen	IBA Inferred from Biological aspect of Ancestor more info
located_in vacuolar lumen	IDA Inferred from Direct Assay more info	PubMed
is_active_in vacuolar membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in vacuole	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: triglyceride lipase ATG15

NP_009994.2

EC 3.1.1.3

Phospholipase B; hydrolyses phosphatidylserine; minor activity against cardiolipin and PtdEtn; required for lysis of autophagic and CVT bodies; targeted to the vacuole via the Pep1p-dependent endosomal VPS pathway; targeted to intravacuolar vesicles during autophagy by the MVB pathway; maintains lipid droplet quantity after the diauxic shift; regulates lipolysis; single membrane spanning protein with cytosolic N-term and the rest in the ER lumen; expression regulated by Yap1p during autophagy

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001135.5 Reference assembly

Range

237214..238776

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001178779.1 → NP_009994.2 TPA: triglyceride lipase ATG15 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_009994.2

Status: REVIEWED

UniProtKB/Swiss-Prot

A6ZTP2, D6VR71, P25641, Q8NIL6

UniProtKB/TrEMBL

N1PAN2

Conserved Domains (1) summary

COG5153
Location:11 → 476

CVT17; Putative lipase essential for disintegration of autophagic bodies inside the vacuole [Intracellular trafficking, secretion, and vesicular transport]