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    FTH1 Fth1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852506, updated on 9-Dec-2024

    Summary

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    Official Symbol
    FTH1
    Official Full Name
    Fth1p
    Primary source
    SGD:S000000411
    Locus tag
    YBR207W
    See related
    AllianceGenome:SGD:S000000411; FungiDB:YBR207W; VEuPathDB:YBR207W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable ferrous iron transmembrane transporter activity. Involved in endocytosis and iron ion transmembrane transport. Located in fungal-type vacuole membrane and membrane raft. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See FTH1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (635146..636543)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene triacylglycerol lipase Neighboring gene mannosyltransferase KTR3 Neighboring gene bifunctional urea carboxylase/allophanate hydrolase Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The iron transporter Fth1p forms a complex with the Fet5 iron oxidase and resides on the vacuolar membrane. Urbanowski JL, et al. J Biol Chem, 1999 Dec 31. PMID 10608875
    2. Iron-regulated DNA binding by the AFT1 protein controls the iron regulon in yeast. Yamaguchi-Iwai Y, et al. EMBO J, 1996 Jul 1. PMID 8670839, Free PMC Article
    3. Assembly, activation, and trafficking of the Fet3p.Ftr1p high affinity iron permease complex in Saccharomyces cerevisiae. Singh A, et al. J Biol Chem, 2006 May 12. PMID 16522632
    4. ESCRT, not intralumenal fragments, sorts ubiquitinated vacuole membrane proteins for degradation. Yang X, et al. J Cell Biol, 2021 Aug 2. PMID 34047770, Free PMC Article
    5. Selective Lysosomal Transporter Degradation by Organelle Membrane Fusion. McNally EK, et al. Dev Cell, 2017 Jan 23. PMID 28017618

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ferrous iron transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables iron ion transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in iron ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in iron ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in iron ion transmembrane transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in iron ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    located_in fungal-type vacuole membrane HDA PubMed 
    is_active_in fungal-type vacuole membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in fungal-type vacuole membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of high-affinity iron permease complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of high-affinity iron permease complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane raft IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in vacuolar membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Fth1p
    NP_009766.4
    • Putative high affinity iron transporter; involved in transport of intravacuolar stores of iron; forms complex with Fet5p; expression is regulated by iron; proposed to play indirect role in endocytosis; protein abundance increases in response to DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      635146..636543
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178555.4 → NP_009766.4  TPA: Fth1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009766.4

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQK4, P38310, Q9URQ1
      UniProtKB/TrEMBL
      A6ZLE8, B3LMV2, B5VEF8, C7GKG9, D3UEV4, G2W9L1, N1P9K5
      Conserved Domains (1) summary
      COG0672
      Location:2 → 465
      FTR1; High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38310.2

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