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    TOM5 Tom5p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856252, updated on 9-Dec-2024

    Summary

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    Official Symbol
    TOM5
    Official Full Name
    Tom5p
    Primary source
    SGD:S000006433
    Locus tag
    YPR133W-A
    See related
    AllianceGenome:SGD:S000006433; FungiDB:YPR133W-A; VEuPathDB:YPR133W-A
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    MOM8A
    Summary
    Contributes to protein transmembrane transporter activity. Involved in mitochondrial outer membrane translocase complex assembly and protein targeting to mitochondrion. Located in mitochondrial outer membrane. Part of mitochondrial outer membrane translocase complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See TOM5 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (797557..797709)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene ribosomal 40S subunit protein S23B Neighboring gene Spn1p Neighboring gene Mss18p Neighboring gene chromatin-binding protein CTF4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structure of the cytosolic domain of TOM5, a mitochondrial import protein. Hammen PK, et al. FEBS Lett, 2000 Feb 18. PMID 10683449
    2. Targeting and assembly of mitochondrial tail-anchored protein Tom5 to the TOM complex depend on a signal distinct from that of tail-anchored proteins dispersed in the membrane. Horie C, et al. J Biol Chem, 2003 Oct 17. PMID 12896971
    3. Just follow the acid chain. Schatz G. Nature, 1997 Jul 10. PMID 9217147
    4. Nucleo-mitochondrial interaction of yeast in response to cadmium sulfide quantum dot exposure. Pasquali F, et al. J Hazard Mater, 2017 Feb 15. PMID 27890358
    5. Role of Tom5 in maintaining the structural stability of the TOM complex of mitochondria. Schmitt S, et al. J Biol Chem, 2005 Apr 15. PMID 15701639

    See all (66) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Daya suggest that the assembly of newly imported Tom40 is directly initiated at the SAM complex (SAM37) by its association with Tom5.
      Title: Assembly of the mitochondrial protein import channel: role of Tom5 in two-stage interaction of Tom40 with the SAM complex.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to protein transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to protein transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mitochondrial outer membrane translocase complex assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein targeting to mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein targeting to mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein targeting to mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial outer membrane HDA PubMed 
    located_in mitochondrial outer membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of mitochondrial outer membrane translocase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mitochondrial outer membrane translocase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Tom5p
    NP_015459.1
    • Component of the TOM (translocase of outer membrane) complex; responsible for recognition and initial import of all mitochondrially directed proteins; involved in transfer of precursors from the Tom70p and Tom20p receptors to the Tom40p pore

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      797557..797709
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184307.1 → NP_015459.1  TPA: Tom5p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015459.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W4D0, P80967
      UniProtKB/TrEMBL
      A6ZX11, B3LK95, B5VTR9, C7GLJ4, C8ZJF6, G2WPU8, N1NVL5
      Conserved Domains (1) summary
      pfam10642
      Location:1 → 47
      Tom5; Mitochondrial import receptor subunit or translocase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P80967.1

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