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    RPC40 DNA-directed RNA polymerase core subunit RPC40 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856226, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RPC40
    Official Full Name
    DNA-directed RNA polymerase core subunit RPC40
    Primary source
    SGD:S000006314
    Locus tag
    YPR110C
    See related
    AllianceGenome:SGD:S000006314; FungiDB:YPR110C; VEuPathDB:YPR110C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    RPC5
    Summary
    Contributes to RNA polymerase I activity and RNA polymerase III activity. Involved in tRNA transcription by RNA polymerase III and transcription by RNA polymerase I. Part of RNA polymerase I complex and RNA polymerase III complex. Used to study Treacher Collins syndrome 2 and hypomyelinating leukodystrophy. Human ortholog(s) of this gene implicated in Treacher Collins syndrome 3 and hypomyelinating leukodystrophy 11. Orthologous to human POLR1C (RNA polymerase I and III subunit C). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See RPC40 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (745828..746835, complement)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene tRNA-Thr Neighboring gene Gld1p Neighboring gene serine/threonine-protein kinase DBF20 Neighboring gene RNA-binding ribosome biosynthesis protein MRD1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. RPC40, a unique gene for a subunit shared between yeast RNA polymerases A and C. Mann C, et al. Cell, 1987 Feb 27. PMID 3815519
    2. Retrotransposons. An RNA polymerase III subunit determines sites of retrotransposon integration. Bridier-Nahmias A, et al. Science, 2015 May 1. PMID 25931562
    3. Treacher Collins syndrome mutations in Saccharomyces cerevisiae destabilize RNA polymerase I and III complex integrity. Walker-Kopp N, et al. Hum Mol Genet, 2017 Nov 1. PMID 28973381, Free PMC Article
    4. Rpc19 and Rpc40, two alpha-like subunits shared by nuclear RNA polymerases I and III, are interchangeable between the fission and budding yeasts. Shpakovski GV, et al. Curr Genet, 1999 Oct. PMID 10541858
    5. Specific interaction and two-dimensional crystallization of histidine tagged yeast RNA polymerase I on nickel-chelating lipids. Bischler N, et al. Biophys J, 1998 Mar. PMID 9512048, Free PMC Article

    See all (126) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to RNA polymerase I activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to RNA polymerase I activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA polymerase I activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to RNA polymerase III activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to RNA polymerase III activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA polymerase III activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA transcription by RNA polymerase III IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transcription by RNA polymerase I IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of DNA-directed RNA polymerase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of RNA polymerase I complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RNA polymerase I complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of RNA polymerase III complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RNA polymerase III complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of nuclear DNA-directed RNA polymerase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    DNA-directed RNA polymerase core subunit RPC40
    NP_015435.1
    • RNA polymerase subunit AC40; common to RNA polymerase I and III; predominant determinant targeting Ty1 integration upstream of Pol III-transcribed genes

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      745828..746835 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184207.1 → NP_015435.1  TPA: DNA-directed RNA polymerase core subunit RPC40 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015435.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W4A9, P07703
      UniProtKB/TrEMBL
      A6ZWZ1, B3LK74, B5VTQ0, C7GXS2, C8ZJD2, G2WPS7, N1NWG0
      Conserved Domains (1) summary
      cd07032
      Location:40 → 330
      RNAP_I_II_AC40; AC40 subunit of Eukaryotic RNA polymerase (RNAP) I and RNAP III
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P07703.1

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