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    RLF2 Rlf2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856129, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RLF2
    Official Full Name
    Rlf2p
    Primary source
    SGD:S000006222
    Locus tag
    YPR018W
    See related
    AllianceGenome:SGD:S000006222; FungiDB:YPR018W; VEuPathDB:YPR018W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    CAC1
    Summary
    Contributes to histone binding activity. Involved in DNA replication-dependent chromatin assembly. Located in chromatin; chromosome, centromeric region; and nucleus. Part of CAF-1 complex. Human ortholog(s) of this gene implicated in colon cancer; high grade glioma; neuroblastoma; and systemic lupus erythematosus. Orthologous to human CHAF1A (chromatin assembly factor 1 subunit A). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See RLF2 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (594476..596296)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene translation initiation factor 6 Neighboring gene guanine nucleotide exchange factor DSS4 Neighboring gene MCM DNA helicase complex subunit MCM4 Neighboring gene F1F0 ATP synthase subunit g

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The yeast Cac1 protein is required for the stable inheritance of transcriptionally repressed chromatin at telomeres. Monson EK, et al. Proc Natl Acad Sci U S A, 1997 Nov 25. PMID 9371803, Free PMC Article
    2. RLF2, a subunit of yeast chromatin assembly factor-I, is required for telomeric chromatin function in vivo. Enomoto S, et al. Genes Dev, 1997 Feb 1. PMID 9030688
    3. Dysfunctional CAF-I reveals its role in cell cycle progression and differential regulation of gene silencing. Rowlands H, et al. Cell Cycle, 2019 Nov. PMID 31564230, Free PMC Article
    4. Interaction between Lim15/Dmc1 and the homologue of the large subunit of CAF-1: a molecular link between recombination and chromatin assembly during meiosis. Ishii S, et al. FEBS J, 2008 May. PMID 18355319
    5. A novel single alpha-helix DNA-binding domain in CAF-1 promotes gene silencing and DNA damage survival through tetrasome-length DNA selectivity and spacer function. Rosas R, et al. Elife, 2023 Jul 11. PMID 37432722, Free PMC Article

    See all (165) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cac1 WHD and PIP domains have distinct roles in replisome progression and genomic stability.
      Title: Cac1 WHD and PIP domains have distinct roles in replisome progression and genomic stability.
    2. Dysfunctional CAF-I reveals its role in cell cycle progression and differential regulation of gene silencing.
      Title: Dysfunctional CAF-I reveals its role in cell cycle progression and differential regulation of gene silencing.
    3. CAF-1 and Asf1 function redundantly to deactivate the checkpoint by restoring chromatin structure on the completion of DNA double-strand break repair.
      Title: Chromatin assembly factors Asf1 and CAF-1 have overlapping roles in deactivating the DNA damage checkpoint when DNA repair is complete.
    4. Cac1p and Kap123 cooperate to ensure that only appropriately acetylated histone H4 proteins are imported into the nucleus
      Title: Yeast chromatin assembly complex 1 protein excludes nonacetylatable forms of histone H4 from chromatin and the nucleus.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to histone binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA replication-dependent chromatin assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in DNA replication-dependent chromatin assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nucleosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of CAF-1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of CAF-1 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromosome, centromeric region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Rlf2p
    NP_015343.1
    • Largest subunit (p90) of the Chromatin Assembly Complex (CAF-1); chromatin assembly by CAF-1 is important for multiple processes including histone H3/H4 tetramerization, silencing at telomeres, mating type loci and rDNA, maintenance of kinetochore structure, deactivation of DNA damage checkpoint after DNA repair, chromatin dynamics during transcription, and repression of divergent noncoding transcription

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      594476..596296
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184115.1 → NP_015343.1  TPA: Rlf2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015343.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W428, Q12495
      UniProtKB/TrEMBL
      A6ZWR1, B3LL79, B5VTH6, C8ZJ43, N1NXG2
      Conserved Domains (1) summary
      pfam12253
      Location:345 → 387
      CAF1A; Chromatin assembly factor 1 subunit A
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12495.1

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