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    TRM44 tRNA (uracil) methyltransferase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856077, updated on 9-Dec-2024

    Summary

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    Official Symbol
    TRM44
    Official Full Name
    tRNA (uracil) methyltransferase
    Primary source
    SGD:S000005951
    Locus tag
    YPL030W
    See related
    AllianceGenome:SGD:S000005951; FungiDB:YPL030W; VEuPathDB:YPL030W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables tRNA (uridine) methyltransferase activity. Involved in tRNA nucleoside ribose methylation. Located in cytoplasm. Orthologous to human TRMT44 (tRNA methyltransferase 44 homolog). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See TRM44 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (493543..495246)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Svl3p Neighboring gene cyclin-dependent serine/threonine-protein kinase PHO85 Neighboring gene ATP-dependent RNA helicase SUV3 Neighboring gene acetyl-CoA C-acetyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A quantitative systems approach reveals dynamic control of tRNA modifications during cellular stress. Chan CT, et al. PLoS Genet, 2010 Dec 16. PMID 21187895, Free PMC Article
    2. Identification of yeast tRNA Um(44) 2'-O-methyltransferase (Trm44) and demonstration of a Trm44 role in sustaining levels of specific tRNA(Ser) species. Kotelawala L, et al. RNA, 2008 Jan. PMID 18025252, Free PMC Article
    3. 2'-O-ribose methylation of transfer RNA promotes recovery from oxidative stress in Saccharomyces cerevisiae. Endres L, et al. PLoS One, 2020. PMID 32053677, Free PMC Article
    4. The yeast rapid tRNA decay pathway competes with elongation factor 1A for substrate tRNAs and acts on tRNAs lacking one or more of several modifications. Dewe JM, et al. RNA, 2012 Oct. PMID 22895820, Free PMC Article
    5. Degradation of several hypomodified mature tRNA species in Saccharomyces cerevisiae is mediated by Met22 and the 5'-3' exonucleases Rat1 and Xrn1. Chernyakov I, et al. Genes Dev, 2008 May 15. PMID 18443146, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA (uridine) methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tRNA (uridine) methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables tRNA (uridine) methyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables tRNA(Ser) (uridine(44)-2'-O-)-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA methylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in tRNA methylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tRNA nucleoside ribose methylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    tRNA (uracil) methyltransferase
    NP_015295.1
    • tRNA(Ser) Um(44) 2'-O-methyltransferase; involved in maintaining levels of the tRNA-Ser species tS(CGA) and tS(UGA); conserved among metazoans and fungi but there does not appear to be a homolog in plants; TRM44 is a non-essential gene

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      493543..495246
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183844.1 → NP_015295.1  TPA: tRNA (uracil) methyltransferase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015295.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3Y3, Q02648, Q03090, Q2XN15
      UniProtKB/TrEMBL
      A6ZWL7, C7GU22, C8ZIZ9, G2WPE8, N1NVI4
      Conserved Domains (1) summary
      pfam07757
      Location:257 → 370
      AdoMet_MTase; Predicted AdoMet-dependent methyltransferase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q02648.1

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