MET12 methylenetetrahydrofolate reductase (NAD(P)H) MET12 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: MET12
Official Full Name: methylenetetrahydrofolate reductase (NAD(P)H) MET12
Primary source: SGD:S000005944
Locus tag: YPL023C
See related: AllianceGenome:SGD:S000005944; FungiDB:YPL023C; VEuPathDB:YPL023C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables methylenetetrahydrofolate reductase (NAD(P)H) activity. Predicted to be involved in methionine biosynthetic process and tetrahydrofolate interconversion. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); cardiovascular system disease (multiple); hematologic cancer (multiple); and liver disease (multiple). Orthologous to human MTHFR (methylenetetrahydrofolate reductase). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See MET12 in Genome Data Viewer

Location:: chromosome: XVI

Exon count:: 1

Sequence:: Chromosome: XVI; NC_001148.4 (504339..506312, complement)

Chromosome XVI - NC_001148.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables FAD binding	IBA Inferred from Biological aspect of Ancestor more info
enables methylenetetrahydrofolate reductase (NAD(P)H) activity	IBA Inferred from Biological aspect of Ancestor more info
enables methylenetetrahydrofolate reductase (NAD(P)H) activity	IDA Inferred from Direct Assay more info	PubMed
enables methylenetetrahydrofolate reductase (NAD(P)H) activity	IEA Inferred from Electronic Annotation more info
enables methylenetetrahydrofolate reductase (NADH) activity	IEA Inferred from Electronic Annotation more info
enables methylenetetrahydrofolate reductase (NADPH) activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in methionine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in methionine metabolic process	IEA Inferred from Electronic Annotation more info
involved_in tetrahydrofolate interconversion	IBA Inferred from Biological aspect of Ancestor more info
involved_in tetrahydrofolate interconversion	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info

General protein information

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Preferred Names: methylenetetrahydrofolate reductase (NAD(P)H) MET12

NP_015302.1

EC 1.5.1.20

Protein with MTHFR activity in vitro; null mutant has no phenotype and is prototrophic for methionine; MET13 encodes major isozyme of methylenetetrahydrofolate reductase (MTHFR)

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001148.4 Reference assembly

Range

504339..506312 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183837.1 → NP_015302.1 TPA: methylenetetrahydrofolate reductase (NAD(P)H) MET12 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_015302.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W3Y9, P46151

UniProtKB/TrEMBL

C7GU28, C8ZJ05, N1P1U1

Conserved Domains (1) summary

cl00246
Location:16 → 643

MTHFR; Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase ...