ULP1 SUMO protease ULP1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: ULP1
Official Full Name: SUMO protease ULP1
Primary source: SGD:S000005941
Locus tag: YPL020C
See related: AllianceGenome:SGD:S000005941; FungiDB:YPL020C; VEuPathDB:YPL020C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: NIB1
Summary: Enables deSUMOylase activity. Involved in G2/M transition of mitotic cell cycle and protein desumoylation. Located in nuclear envelope and nucleolus. Orthologous to several human genes including SENP1 (SUMO specific peptidase 1) and SENP2 (SUMO specific peptidase 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ULP1 in Genome Data Viewer

Location:: chromosome: XVI

Exon count:: 1

Sequence:: Chromosome: XVI; NC_001148.4 (512313..514178, complement)

Chromosome XVI - NC_001148.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Authors show that dosage of SUMO isopeptidase, Ulp1, is important for regulation of TPE. Moderate elevation of Ulp1 reduces silencing of both, the euchromatic gene placed proximal to telomeric repeats and the sub-telomeric genes that are silenced by TPE.
Title: Elevated dosage of Ulp1 disrupts telomeric silencing in Saccharomyces cerevisiae.
Mutations or physiological perturbations altering nuclear pore integrity decrease the levels of the nuclear pore complex (NPC)-associated SUMO protease Ulp1 and trigger the accumulation of sumoylated versions of Hek2 unable to bind NPC mRNAs. Study results support the existence of a quality control mechanism involving Ulp1 as a sensor of NPC integrity and Hek2 as a repressor of NPC biogenesis in budding yeast.
Title: A SUMO-dependent feedback loop senses and controls the biogenesis of nuclear pore subunits.
Detailed comparison of the SUMO-binding activity of the budding yeast protein Ulp1 (ScUlp1) and its ortholog in the thermotolerant yeast Kluyveromyces marxianus, KmUlp1. We find that the catalytic UD domains of both ScUlp1 and KmUlp1 show a high degree of sequence conservation, complement a ulp1Delta mutant in vivo, and process a SUMO precursor in vitro.
Title: SUMO targeting of a stress-tolerant Ulp1 SUMO protease.
our data highlight a role for the NPC-associated SUMO protease Ulp1 in regulating the sumoylation of gene-bound transcription regulators.
Title: The nuclear pore regulates GAL1 gene transcription by controlling the localization of the SUMO protease Ulp1.
A prominent ~50-kDa sumoylated protein accumulates in a Ulp1 coiled-coil domain mutant; that was identified as Scs2, an endoplasmic reticulum (ER) membrane protein that regulates phosphatidylinositol synthesis and lipid trafficking.
Title: Desumoylation of the endoplasmic reticulum membrane VAP family protein Scs2 by Ulp1 and SUMO regulation of the inositol synthesis pathway.
Data characterize a novel mode of SUMO system control: in response to elevated alcohol levels, the Saccharomyces cerevisiae SUMO protease Ulp1 is disengaged from its usual location at the nuclear pore complex (NPC) and sequestered in the nucleolus.
Title: A novel mechanism for SUMO system control: regulated Ulp1 nucleolar sequestration.
Data show that Esc1 and Ulp1 help retain unspliced pre-mRNAs in the nucleus, and are essential for proper nuclear basket function, which includes mRNA surveillance and regulation of SUMO protein dynamics.
Title: A nuclear envelope protein linking nuclear pore basket assembly, SUMO protease regulation, and mRNA surveillance.
Nucleoporins are required for maintenance of proper Ulp1 levels at nuclear pore complexes and for the establishment of the appropriate sumoylation of several cellular proteins.
Title: Nucleoporins prevent DNA damage accumulation by modulating Ulp1-dependent sumoylation processes.
Mlps play important roles in regulating Ulp1 and subsequently affect sumoylation stasis, growth, and DNA repair.
Title: Mlp-dependent anchorage and stabilization of a desumoylating enzyme is required to prevent clonal lethality.
missegregation of a fluorescently tagged 2 microm circle reporter plasmid in a subset of ulp1 mutant cells suggest that Smt3 modification plays a role in both plasmid copy number control and segregation
Title: The 2 microm plasmid causes cell death in Saccharomyces cerevisiae with a mutation in Ulp1 protease.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables cysteine-type peptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables cysteine-type peptidase activity	IEA Inferred from Electronic Annotation more info
enables deSUMOylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables deSUMOylase activity	IDA Inferred from Direct Assay more info	PubMed
enables deSUMOylase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables ubiquitin-like protein peptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G2/M transition of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein desumoylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein desumoylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein desumoylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nuclear envelope	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: SUMO protease ULP1

NP_015305.1

EC 3.4.22.68

Protease that specifically cleaves Smt3p protein conjugates; required for cell cycle progression; associates with nucleoporins and may interact with septin rings during telophase; contributes to regulation of telomeric silencing; sequestered to the nucleolus under stress conditions

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001148.4 Reference assembly

Range

512313..514178 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183834.1 → NP_015305.1 TPA: SUMO protease ULP1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_015305.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W3Z2, Q02724

UniProtKB/TrEMBL

B3LL43, B5VTE2, G2WPF8

Conserved Domains (1) summary

COG5160
Location:36 → 621

ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]