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    VTC3 vacuolar transporter chaperone [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856088, updated on 9-Dec-2024

    Summary

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    Official Symbol
    VTC3
    Official Full Name
    vacuolar transporter chaperone
    Primary source
    SGD:S000005940
    Locus tag
    YPL019C
    See related
    AllianceGenome:SGD:S000005940; FungiDB:YPL019C; VEuPathDB:YPL019C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    PHM2
    Summary
    Enables calmodulin binding activity. Involved in several processes, including microautophagy; polyphosphate metabolic process; and vacuole fusion, non-autophagic. Located in endoplasmic reticulum and fungal-type vacuole membrane. Part of vacuolar transporter chaperone complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See VTC3 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (514511..517018, complement)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Ecm23p Neighboring gene SUMO protease ULP1 Neighboring gene Ctf19p Neighboring gene Irc15p Neighboring gene Swi1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The macro domain as fusion tag for carrier-driven crystallization. Wild R, et al. Protein Sci, 2017 Feb. PMID 27774698, Free PMC Article
    2. Inositol pyrophosphates activate the vacuolar transport chaperone complex in yeast by disrupting a homotypic SPX domain interaction. Pipercevic J, et al. Nat Commun, 2023 May 8. PMID 37156835, Free PMC Article
    3. Catalytic core of a membrane-associated eukaryotic polyphosphate polymerase. Hothorn M, et al. Science, 2009 Apr 24. PMID 19390046
    4. Coupled synthesis and translocation restrains polyphosphate to acidocalcisome-like vacuoles and prevents its toxicity. Gerasimaitė R, et al. J Cell Sci, 2014 Dec 1. PMID 25315834
    5. Role of the Vtc proteins in V-ATPase stability and membrane trafficking. Müller O, et al. J Cell Sci, 2003 Mar 15. PMID 12584253

    See all (62) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables calmodulin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in microautophagy IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in microautophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in polyphosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in polyphosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in polyphosphate metabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in polyphosphate metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vacuolar transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in vacuolar transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vacuole fusion, non-autophagic IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in autophagosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell cortex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fungal-type vacuole membrane HDA PubMed 
    is_active_in fungal-type vacuole membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in fungal-type vacuole membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuolar membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of vacuolar transporter chaperone complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of vacuolar transporter chaperone complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of vacuolar transporter chaperone complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    vacuolar transporter chaperone
    NP_015306.1
    • Regulatory subunit of vacuolar transporter chaperone (VTC) complex; involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion; important regulator of substrate invagination from the vacuolar membrane; targeted to vacuole via AP-3 pathway; VTC3 has a paralog, VTC2, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      514511..517018 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183833.1 → NP_015306.1  TPA: vacuolar transporter chaperone [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015306.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3Z3, Q02725
      UniProtKB/TrEMBL
      C8ZJ09, G2WPF9, N1P1U8
      Conserved Domains (2) summary
      COG5036
      Location:1 → 561
      COG5036; SPX domain-containing protein involved in vacuolar polyphosphate accumulation [Inorganic ion transport and metabolism, Intracellular trafficking, secretion, and vesicular transport]
      COG5264
      Location:673 → 803
      VTC1; Vacuolar transporter chaperone [Posttranslational modification, protein turnover, chaperones]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q02725.1

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