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    PIN2 Pin2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854271, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PIN2
    Official Full Name
    Pin2p
    Primary source
    SGD:S000005630
    Locus tag
    YOR104W
    See related
    AllianceGenome:SGD:S000005630; FungiDB:YOR104W; VEuPathDB:YOR104W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Located in cellular bud neck and plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See PIN2 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (517642..518490)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Ras family GTPase RAS1 Neighboring gene dolichyl-diphosphooligosaccharide-protein glycotransferase Neighboring gene uncharacterized protein Neighboring gene SNAP receptor VAM3 Neighboring gene GTPase-activating protein RGS2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Prions affect the appearance of other prions: the story of [PIN(+)]. Derkatch IL, et al. Cell, 2001 Jul 27. PMID 11511345
    2. A bipolar functionality of Q/N-rich proteins: Lsm4 amyloid causes clearance of yeast prions. Oishi K, et al. Microbiologyopen, 2013 Jun. PMID 23512891, Free PMC Article
    3. The Functional Specialization of Exomer as a Cargo Adaptor During the Evolution of Fungi. Anton C, et al. Genetics, 2018 Apr. PMID 29437703, Free PMC Article
    4. The prion-like domain in the exomer-dependent cargo Pin2 serves as a trans-Golgi retention motif. Ritz AM, et al. Cell Rep, 2014 Apr 10. PMID 24656818
    5. Dynamic assembly of the exomer secretory vesicle cargo adaptor subunits. Huranova M, et al. EMBO Rep, 2016 Feb. PMID 26742961, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular bud neck IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cellular bud neck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in fungal-type vacuole membrane HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Pin2p
    NP_014747.1
    • Exomer-dependent cargo protein; induces appearance of [PIN+] prion when overproduced; prion-like domain serves as a retention signal in the trans-Golgi network; predicted to be palmitoylated

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      517642..518490
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183523.1 → NP_014747.1  TPA: Pin2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014747.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W2G4, Q12057
      UniProtKB/TrEMBL
      A6ZNV3, B3LJE9, B5VRZ6, C7GMN1, G2WMY0, N1P338
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12057.1

    Gene LinkOut

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