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    SKI7 Ski7p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854243, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SKI7
    Official Full Name
    Ski7p
    Primary source
    SGD:S000005602
    Locus tag
    YOR076C
    See related
    AllianceGenome:SGD:S000005602; FungiDB:YOR076C; VEuPathDB:YOR076C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables GTP binding activity and protein-macromolecule adaptor activity. Involved in RNA catabolic process and protein catabolic process. Located in cytoplasm. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SKI7 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (469377..471620, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene thymidylate synthase Neighboring gene Ufe1p Neighboring gene Rts2p Neighboring gene Bud21p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Crystallization and preliminary X-ray analysis of the C-terminal fragment of Ski7 from Saccharomyces cerevisiae. Lee JY, et al. Acta Crystallogr F Struct Biol Commun, 2014 Sep. PMID 25195903, Free PMC Article
    2. Saccharomyces cerevisiae Ski7 Is a GTP-Binding Protein Adopting the Characteristic Conformation of Active Translational GTPases. Kowalinski E, et al. Structure, 2015 Jul 7. PMID 26051716, Free PMC Article
    3. Translation of aberrant mRNAs lacking a termination codon or with a shortened 3'-UTR is repressed after initiation in yeast. Inada T, et al. EMBO J, 2005 Apr 20. PMID 15933721, Free PMC Article
    4. A short splicing isoform of HBS1L links the cytoplasmic exosome and SKI complexes in humans. Kalisiak K, et al. Nucleic Acids Res, 2017 Feb 28. PMID 28204585, Free PMC Article
    5. The ski7 antiviral protein is an EF1-alpha homolog that blocks expression of non-Poly(A) mRNA in Saccharomyces cerevisiae. Benard L, et al. J Virol, 1999 Apr. PMID 10074137, Free PMC Article

    See all (98) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The authors report strong genetic evidence suggesting differential roles for Ski7 N-terminal and Ski7 C-terminal domains in normal and specific mRNA turnover pathways by creating/isolating mutations in conserved motifs using indicator yeast strains.
      Title: Mutations in the G-domain of Ski7 cause specific dysfunction in non-stop decay.
    2. Cytoplasmic Ski7 and nuclear Rrp6 bind Exo10 using similar surfaces and recognition motifs.
      Title: Structure of a Cytoplasmic 11-Subunit RNA Exosome Complex.
    3. Crysta structure of Saccharomyces cerevisiae Ski7.
      Title: Saccharomyces cerevisiae Ski7 Is a GTP-Binding Protein Adopting the Characteristic Conformation of Active Translational GTPases.
    4. Ski7p interacts with the Ski complex via its interaction with Ski8p and Ski3p.
      Title: Domain interactions within the Ski2/3/8 complex and between the Ski complex and Ski7p.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables GTP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-containing complex binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein-macromolecule adaptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in nonfunctional rRNA decay IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nuclear-transcribed mRNA catabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in nuclear-transcribed mRNA catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nuclear-transcribed mRNA catabolic process, non-stop decay IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein catabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol HDA PubMed 

    General protein information

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    Preferred Names
    Ski7p
    NP_014719.1
    • GTP-binding protein that couples the Ski complex and exosome; putative pseudo-translational GTPase involved in 3'-to-5' mRNA decay pathway; interacts with both the cytoplasmic exosome and the Ski complex; eRF3-like domain targets nonstop mRNA for degradation; null mutants have a superkiller phenotype; SKI7 has a paralog, HBS1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      469377..471620 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183495.1 → NP_014719.1  TPA: Ski7p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014719.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W2D9, O00032, Q08491
      UniProtKB/TrEMBL
      A6ZNS8
      Conserved Domains (1) summary
      COG5256
      Location:261 → 747
      TEF1; Translation elongation factor EF-1alpha (GTPase) [Translation, ribosomal structure and biogenesis]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08491.1

    Gene LinkOut

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