TOM22 Tom22p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: TOM22
Official Full Name: Tom22p
Primary source: SGD:S000005075
Locus tag: YNL131W
See related: AllianceGenome:SGD:S000005075; FungiDB:YNL131W; VEuPathDB:YNL131W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: MAS17; MAS22; MOM22
Summary: Contributes to protein transmembrane transporter activity. Involved in protein import into mitochondrial matrix and protein insertion into mitochondrial outer membrane. Located in mitochondrial outer membrane. Part of mitochondrial outer membrane translocase complex. Orthologous to human TOMM22 (translocase of outer mitochondrial membrane 22). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See TOM22 in Genome Data Viewer

Location:: chromosome: XIV

Exon count:: 1

Sequence:: Chromosome: XIV; NC_001146.8 (378767..379225)

Chromosome XIV - NC_001146.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Structural snapshot of the mitochondrial protein import gate.
Title: Structural snapshot of the mitochondrial protein import gate.
Por1 appears to contribute to cell-cycle-dependent variation of the functional trimeric TOM complex by chaperoning monomeric Tom22, which arises from the cell-cycle-controlled variation of phosphorylated Tom6.
Title: Porin Associates with Tom22 to Regulate the Mitochondrial Protein Gate Assembly.
Sam37 interacts with the receptor domain of Tom22 on the cytosolic side of the mitochondrial outer membrane and links TOM and SAM complexes.
Title: Sam37 is crucial for formation of the mitochondrial TOM-SAM supercomplex, thereby promoting β-barrel biogenesis.
Results show the relation between the identified presequence-binding region of Tom40 and the intermembrane space domain of Tom22. The identified presequence of Tom40 is capable of functioning independently of trans-acting TOM presequence-binding domain.
Title: Presequence recognition by the tom40 channel contributes to precursor translocation into the mitochondrial matrix.
Tom22 is regulated by the cytosolic kinases CK2 and PKA and by membranebound CK1.
Title: Glucose-induced regulation of protein import receptor Tom22 by cytosolic and mitochondria-bound kinases.
Study shows that the cytosolic domain of Tom22 links the outer mitochondrial membrane and the sorting and assembly machinery into a supercomplex, facilitating precursor transfer on the intermembrane space side and reveals receptor-mediated coupling of import and export translocases as a means of precursor channeling.
Title: Coupling of mitochondrial import and export translocases by receptor-mediated supercomplex formation.
Data Show that Tom22 are anchored in the outer membrane by a single transmembrane alpha-helix, located in the C-terminal portion of Tom22 (tail-anchored) and insertion of the precursor of Tom22 into the outer membrane requires pre-existing Tom receptors.
Title: Biogenesis of the mitochondrial TOM complex: Mim1 promotes insertion and assembly of signal-anchored receptors.
beta2GP1-dependent uptake is mediated by bridging of the target cell to the phagocyte through the protein C- and N-terminal domains, respectively
Title: Tom20 and Tom22 share the common signal recognition pathway in mitochondrial protein import.
We also identified a core sequence of Tom22 that binds to Tim21. Furthermore, negatively charged amino-acid residues of Tom22 are important for binding to Tim21. Here we suggest a mechanism for the TOM-TIM interaction.
Title: The Tim21 binding domain connects the preprotein translocases of both mitochondrial membranes.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
contributes_to protein transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in protein import into mitochondrial matrix	IEA Inferred from Electronic Annotation more info
involved_in protein import into mitochondrial matrix	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein insertion into mitochondrial outer membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrial outer membrane	HDA more info	PubMed
located_in mitochondrial outer membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
part_of mitochondrial outer membrane translocase complex	IDA Inferred from Direct Assay more info	PubMed
part_of mitochondrial outer membrane translocase complex	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Tom22p

NP_014268.1

Component of the TOM (Translocase of Outer Membrane) complex; responsible for initial import of mitochondrially directed proteins; mediates interaction between TOM and TIM complexes and acts as receptor for precursor proteins; implicated in mitochondrial accumulation of amyloid beta peptides via direct interaction with amyloid beta peptide residues 25-42 followed by transfer to Tom40p and transport through the TOM channel