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    WSC2 Wsc2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855438, updated on 9-Dec-2024

    Summary

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    Official Symbol
    WSC2
    Official Full Name
    Wsc2p
    Primary source
    SGD:S000005227
    Locus tag
    YNL283C
    See related
    AllianceGenome:SGD:S000005227; FungiDB:YNL283C; VEuPathDB:YNL283C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    STA3
    Summary
    Enables transmembrane signaling receptor activity. Involved in Rho protein signal transduction; fungal-type cell wall organization; and response to heat. Located in cellular bud neck and plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See WSC2 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (105184..106695, complement)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene mitochondrial 54S ribosomal protein YmL10/YmL18 Neighboring gene tRNA-Thr Neighboring gene Pop3p Neighboring gene Hch1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A block of endocytosis of the yeast cell wall integrity sensors Wsc1 and Wsc2 results in reduced fitness in vivo. Wilk S, et al. Mol Genet Genomics, 2010 Sep. PMID 20652590
    2. The cell wall integrity/remodeling MAPK cascade is involved in glucose activation of the yeast plasma membrane H(+)-ATPase. de la Fuente N, et al. Biochim Biophys Acta, 2000 Dec 20. PMID 11118530
    3. Characterization of the Wsc1 protein, a putative receptor in the stress response of Saccharomyces cerevisiae. Lodder AL, et al. Genetics, 1999 Aug. PMID 10430578, Free PMC Article
    4. Heat-induced cell cycle arrest of Saccharomyces cerevisiae: involvement of the RAD6/UBC2 and WSC2 genes in its reversal. Raboy B, et al. Mol Microbiol, 1999 May. PMID 10361277
    5. Mid2 is a putative sensor for cell integrity signaling in Saccharomyces cerevisiae. Rajavel M, et al. Mol Cell Biol, 1999 Jun. PMID 10330137, Free PMC Article

    See all (67) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Protein Interactions of the Mechanosensory Proteins Wsc2 and Wsc3 for Stress Resistance in Saccharomyces cerevisiae.
      Title: Protein Interactions of the Mechanosensory Proteins Wsc2 and Wsc3 for Stress Resistance in Saccharomyces cerevisiae.
    2. Data show that Wsc1 uses a clathrin-dependent NPFDD signal, Wsc2 relies on a specific lysine residue (K495).
      Title: A block of endocytosis of the yeast cell wall integrity sensors Wsc1 and Wsc2 results in reduced fitness in vivo.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables transmembrane signaling receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Rho protein signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell wall organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fungal-type cell wall organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to heat IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell periphery IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cellular bud IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cellular bud neck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm HDA PubMed 
    located_in fungal-type vacuole HDA PubMed 
    located_in mating projection tip HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in site of polarized growth IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Wsc2p
    NP_014116.1
    • Sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway; involved in maintenance of cell wall integrity and recovery from heat shock; required for the arrest of secretion response; WSC2 has a paralog, WSC3, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      105184..106695 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183121.1 → NP_014116.1  TPA: Wsc2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014116.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W0R1, P53832
      UniProtKB/TrEMBL
      A6ZRG2, C8ZGN8, G2WLI3, N1P4Y1
      Conserved Domains (1) summary
      smart00321
      Location:25 → 118
      WSC; present in yeast cell wall integrity and stress response component proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53832.1

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