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    SDD2 Sdd2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855096, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SDD2
    Official Full Name
    Sdd2p
    Primary source
    SGD:S000004678
    Locus tag
    YMR074C
    See related
    AllianceGenome:SGD:S000004678; FungiDB:YMR074C; VEuPathDB:YMR074C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable DNA binding activity. Acts upstream of or within apoptotic process. Located in cytoplasm and nucleus. Orthologous to human PDCD5 (programmed cell death 5). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SDD2 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (413036..413473, complement)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene DNA-binding protein ABF2 Neighboring gene Irc21p Neighboring gene Rco1p Neighboring gene uncharacterized protein Neighboring gene Pds5p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Solution structure of S. cerevisiae PDCD5-like protein and its promoting role in H(2)O(2)-induced apoptosis in yeast. Hong J, et al. Biochemistry, 2009 Jul 28. PMID 19469552
    2. A cytosolic network suppressing mitochondria-mediated proteostatic stress and cell death. Wang X, et al. Nature, 2015 Aug 27. PMID 26192197, Free PMC Article
    3. Chaperone control of the activity and specificity of the histone H3 acetyltransferase Rtt109. Fillingham J, et al. Mol Cell Biol, 2008 Jul. PMID 18458063, Free PMC Article
    4. The interaction network of the chaperonin CCT. Dekker C, et al. EMBO J, 2008 Jul 9. PMID 18511909, Free PMC Article
    5. Yeast Saccharomyces cerevisiae adiponectin receptor homolog Izh2 is involved in the regulation of zinc, phospholipid and pH homeostasis. Mattiazzi Ušaj M, et al. Metallomics, 2015 Sep. PMID 26067383

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Sdd2p
    NP_013790.1
    • Protein with homology to human PDCD5; PDCD5 is involved in programmed cell death; N-terminal region forms a conserved triple-helix bundle structure; overproduction suppresses lethality due to expression of the dominant PET9 allele AAC2-A128P; overexpression promotes H2O2-induced apoptosis; YMR074C is not an essential gene; protein abundance increases in response to DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      413036..413473 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182572.1 → NP_013790.1  TPA: Sdd2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013790.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZP8, Q04773
      UniProtKB/TrEMBL
      A6ZMD3, B3LLW7, B5VPK0, C7GL50, C8ZES6, G2WKC2
      Conserved Domains (1) summary
      COG2118
      Location:1 → 118
      PDCD5; DNA-binding TFAR19-related protein, PDSD5 family [General function prediction only]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q04773.1

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