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    FAR8 Far8p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855044, updated on 9-Dec-2024

    Summary

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    Official Symbol
    FAR8
    Official Full Name
    Far8p
    Primary source
    SGD:S000004631
    Locus tag
    YMR029C
    See related
    AllianceGenome:SGD:S000004631; FungiDB:YMR029C; VEuPathDB:YMR029C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in re-entry into mitotic cell cycle after pheromone arrest. Located in endoplasmic reticulum. Orthologous to human STRN (striatin). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See FAR8 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (328660..330231, complement)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene putative methyltransferase Neighboring gene Tap42p Neighboring gene Rsf1p Neighboring gene Eis1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The PP2A-like phosphatase Ppg1 mediates assembly of the Far complex to balance gluconeogenic outputs and enables adaptation to glucose depletion. Niphadkar S, et al. PLoS Genet, 2024 Mar. PMID 38452140, Free PMC Article
    2. Tiered assembly of the yeast Far3-7-8-9-10-11 complex at the endoplasmic reticulum. Pracheil T, et al. J Biol Chem, 2013 Jun 7. PMID 23625923, Free PMC Article
    3. Far3 and five interacting proteins prevent premature recovery from pheromone arrest in the budding yeast Saccharomyces cerevisiae. Kemp HA, et al. Mol Cell Biol, 2003 Mar. PMID 12588993, Free PMC Article
    4. Functional repurposing revealed by comparing S. pombe and S. cerevisiae genetic interactions. Frost A, et al. Cell, 2012 Jun 8. PMID 22682253, Free PMC Article
    5. Association and dissociation between the mitochondrial Far complex and Atg32 regulate mitophagy. Innokentev A, et al. Elife, 2020 Dec 15. PMID 33317697, Free PMC Article

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in re-entry into mitotic cell cycle after pheromone arrest IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of FAR/SIN/STRIPAK complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol HDA PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Far8p
    NP_013742.1
    • Protein involved in recovery from arrest in response to pheromone; acts in a cell cycle arrest recovery pathway independent from Far1p; interacts with Far3p, Far7p, Far9p, Far10p, and Far11p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      328660..330231 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182525.1 → NP_013742.1  TPA: Far8p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013742.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZK3, Q05040
      UniProtKB/TrEMBL
      C8ZEN5, N1P5C9
      Conserved Domains (1) summary
      pfam08232
      Location:14 → 54
      Striatin; Striatin family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q05040.1

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