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    MIX17 Mix17p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855014, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MIX17
    Official Full Name
    Mix17p
    Primary source
    SGD:S000004604
    Locus tag
    YMR002W
    See related
    AllianceGenome:SGD:S000004604; FungiDB:YMR002W; VEuPathDB:YMR002W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    MIC17
    Summary
    Involved in aerobic respiration. Located in mitochondrial intermembrane space. Used to study frontotemporal dementia and/or amyotrophic lateral sclerosis 2; isolated mitochondrial myopathy; and spinal muscular atrophy, Jokela type. Human ortholog(s) of this gene implicated in Parkinson's disease 22; frontotemporal dementia and/or amyotrophic lateral sclerosis 2; isolated mitochondrial myopathy; and spinal muscular atrophy, Jokela type. Orthologous to human CHCHD10 (coiled-coil-helix-coiled-coil-helix domain containing 10); CHCHD2 (coiled-coil-helix-coiled-coil-helix domain containing 2); and CHCHD2P9 (coiled-coil-helix-coiled-coil-helix domain containing 2 pseudogene 9). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See MIX17 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (272193..272663)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene polo kinase CDC5 Neighboring gene uncharacterized protein Neighboring gene Aim34p Neighboring gene Mvp1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Novel mitochondrial intermembrane space proteins as substrates of the MIA import pathway. Gabriel K, et al. J Mol Biol, 2007 Jan 19. PMID 17095012
    2. A discrete pathway for the transfer of intermembrane space proteins across the outer membrane of mitochondria. Gornicka A, et al. Mol Biol Cell, 2014 Dec 15. PMID 25318675, Free PMC Article
    3. Mistargeted mitochondrial proteins activate a proteostatic response in the cytosol. Wrobel L, et al. Nature, 2015 Aug 27. PMID 26245374
    4. Systematic analysis of the twin cx(9)c protein family. Longen S, et al. J Mol Biol, 2009 Oct 23. PMID 19703468
    5. Yeast Nst1 is a novel component of P-bodies and is a specific suppressor of proteasome base assembly defects. Cheng CL, et al. Mol Biol Cell, 2021 Oct 1. PMID 34347506, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in aerobic respiration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrion organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrion organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in mitochondrial intermembrane space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial intermembrane space IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Mix17p
    NP_013715.1
    • Mitochondrial intermembrane space protein; required for normal oxygen consumption; contains twin cysteine-x9-cysteine motifs; protein abundance increases in response to DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      272193..272663
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182498.1 → NP_013715.1  TPA: Mix17p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013715.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZH7, Q03667
      UniProtKB/TrEMBL
      A6ZM64, C8ZEK8, N1P5B3
      Conserved Domains (1) summary
      pfam06747
      Location:118 → 152
      CHCH; CHCH domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03667.1

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