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    PLB1 lysophospholipase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855020, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PLB1
    Official Full Name
    lysophospholipase
    Primary source
    SGD:S000004610
    Locus tag
    YMR008C
    See related
    AllianceGenome:SGD:S000004610; FungiDB:YMR008C; VEuPathDB:YMR008C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables lysophospholipase activity. Involved in phosphatidylcholine acyl-chain remodeling. Located in endoplasmic reticulum; periplasmic space; and plasma membrane. Orthologous to several human genes including PLA2G4C (phospholipase A2 group IVC) and PLA2G4F (phospholipase A2 group IVF). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See PLB1 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (280590..282584, complement)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene lysophospholipase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene acireductone dioxygenase (Ni2+-requiring)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Phospholipase B from the plasma membrane of Saccharomyces cerevisiae. Separation of two forms with different carbohydrate content. Witt W, et al. Biochim Biophys Acta, 1984 Aug 15. PMID 6380591
    2. The Saccharomyces cerevisiae PLB1 gene encodes a protein required for lysophospholipase and phospholipase B activity. Lee KS, et al. J Biol Chem, 1994 Aug 5. PMID 8051052
    3. Yeast cells accumulate excess endogenous palmitate in phosphatidylcholine by acyl chain remodeling involving the phospholipase B Plb1p. De Smet CH, et al. Biochim Biophys Acta, 2013 Jun. PMID 23501167
    4. Evidence for an intrinsic toxicity of phosphatidylcholine to Sec14p-dependent protein transport from the yeast Golgi complex. Xie Z, et al. Mol Biol Cell, 2001 Apr. PMID 11294911, Free PMC Article
    5. The PLB2 gene of Saccharomyces cerevisiae confers resistance to lysophosphatidylcholine and encodes a phospholipase B/lysophospholipase. Fyrst H, et al. Biochemistry, 1999 May 4. PMID 10231538

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ypk1 and Plb1 interact to alter sphingolipid metabolism up-regulates PLB1 expression via Crz1
      Title: Loss of Ypk1, the yeast homolog to the human serum- and glucocorticoid-induced protein kinase, accelerates phospholipase B1-mediated phosphatidylcholine deacylation.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lysophospholipase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lysophospholipase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables phospholipase A2 activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phospholipase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in glycerophospholipid catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycerophospholipid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphatidylcholine acyl-chain remodeling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phospholipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in extracellular region IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in periplasmic space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane HDA PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    lysophospholipase
    NP_013721.1
    • Phospholipase B (lysophospholipase) involved in lipid metabolism; required for efficient acyl chain remodeling of newly synthesized phosphatidylethanolamine-derived phosphatidylcholine; required for deacylation of phosphatidylcholine and phosphatidylethanolamine but not phosphatidylinositol; PLB1 has a paralog, PLB3, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      280590..282584 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182504.1 → NP_013721.1  TPA: lysophospholipase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013721.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZI2, P39105, Q6B2E2
      UniProtKB/TrEMBL
      A6ZM69, G2WK58, N1P052
      Conserved Domains (1) summary
      smart00022
      Location:16 → 580
      PLAc; Cytoplasmic phospholipase A2, catalytic subunit
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P39105.2

    Gene LinkOut

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