U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    TCB3 Tcb3p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854903, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    TCB3
    Official Full Name
    Tcb3p
    Primary source
    SGD:S000004537
    Locus tag
    YML072C
    See related
    AllianceGenome:SGD:S000004537; FungiDB:YML072C; VEuPathDB:YML072C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables phospholipid binding activity. Involved in endoplasmic reticulum membrane organization; intermembrane phospholipid transfer; and regulation of phosphatidylinositol dephosphorylation. Acts upstream of or within ER to Golgi ceramide transport and phospholipid homeostasis. Located in cellular bud and cortical endoplasmic reticulum. Orthologous to human ESYT1 (extended synaptotagmin 1) and ESYT2 (extended synaptotagmin 2). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See TCB3 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (124730..129367, complement)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene peptidylprolyl isomerase FPR3 Neighboring gene ribosomal 60S subunit protein L6A Neighboring gene Golgi transport complex subunit COG8 Neighboring gene tRNA-Arg

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Calcium-dependent and -independent lipid transfer mediated by tricalbins in yeast. Qian T, et al. J Biol Chem, 2021 Jan-Jun. PMID 33933446, Free PMC Article
    2. Evolutionary Engineering Improves Tolerance for Replacement Jet Fuels in Saccharomyces cerevisiae. Brennan TC, et al. Appl Environ Microbiol, 2015 May 15. PMID 25746998, Free PMC Article
    3. Tricalbins Are Required for Non-vesicular Ceramide Transport at ER-Golgi Contacts and Modulate Lipid Droplet Biogenesis. Ikeda A, et al. iScience, 2020 Oct 23. PMID 33205016, Free PMC Article
    4. Beta-strand recombination in tricalbin evolution and the origin of synaptotagmin-like C2 domains. Jiménez JL, et al. Proteins, 2007 Aug 15. PMID 17510957
    5. ER-plasma membrane contact sites deliver ER lipids and proteins for rapid cell surface expansion. Smith M, et al. J Cell Biol, 2024 Dec 2. PMID 39302311,

    See all (85) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables calcium-dependent phospholipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lipid binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phospholipid binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ER to Golgi ceramide transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within ER to Golgi ceramide transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endoplasmic reticulum membrane organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endoplasmic reticulum membrane organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in endoplasmic reticulum-plasma membrane tethering IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intermembrane phospholipid transfer IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in intermembrane phospholipid transfer IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phospholipid homeostasis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of phosphatidylinositol dephosphorylation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cellular bud IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cortical endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Tcb3p
    NP_013639.1
    • Lipid-binding ER tricalbin involved in ER-plasma membrane tethering; one of at least 7 proteins (Ice2p, Ist2p, Scs2/Scs22p, Tcb1-Tcb3p) that affect cER tethering and contact with the plasma membrane; regulates PI4P levels by controlling access of Sac1p to its substrate PI4P in the PM; regulates PM phospholipid homeostasis; involved in intermembrane phospholipid transfer; also localizes to the mitochondria in a phosphorylated state and is enriched in bud membranes; mRNA is targeted to the bud tip

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      124730..129367 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182431.1 → NP_013639.1  TPA: Tcb3p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013639.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZA1, Q03640
      UniProtKB/TrEMBL
      G2WJY3
      Conserved Domains (1) summary
      COG5038
      Location:44 → 1335
      COG5038; Ca2+-dependent lipid-binding protein, contains C2 domain [General function prediction only]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03640.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools