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    St18 suppression of tumorigenicity 18 [ Mus musculus (house mouse) ]

    Gene ID: 240690, updated on 9-Dec-2024

    Summary

    Official Symbol
    St18provided by MGI
    Official Full Name
    suppression of tumorigenicity 18provided by MGI
    Primary source
    MGI:MGI:2446700
    See related
    Ensembl:ENSMUSG00000033740 AllianceGenome:MGI:2446700
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Myt3; Nzf3; NZF-3; mKIAA0535
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including cytokine-mediated signaling pathway; positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway; and regulation of transcription by RNA polymerase II. Predicted to be part of protein-DNA complex. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; eye; foregut-midgut junction; future brain; and olfactory epithelium. Orthologous to human ST18 (ST18 C2H2C-type zinc finger transcription factor). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in cerebellum adult (RPKM 6.1), CNS E11.5 (RPKM 3.2) and 5 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See St18 in Genome Data Viewer
    Location:
    1 A1; 1 1.89 cM
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (6557455..6931164)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (6487231..6860940)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene ALK and LTK ligand 1 Neighboring gene STARR-positive B cell enhancer ABC_E8980 Neighboring gene STARR-seq mESC enhancer starr_00081 Neighboring gene uncharacterized protein C9orf40 homolog pseudogene Neighboring gene motile sperm domain containing 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_00082 Neighboring gene STARR-seq mESC enhancer starr_00083 Neighboring gene STARR-seq mESC enhancer starr_00085 Neighboring gene STARR-seq mESC enhancer starr_00086 Neighboring gene calmodulin regulated spectrin-associated protein 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_00087 Neighboring gene STARR-seq mESC enhancer starr_00089 Neighboring gene predicted gene, 37108 Neighboring gene high mobility group box 1-like pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-DNA complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of protein-DNA complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    suppression of tumorigenicity 18 protein
    Names
    neural zinc finger protein NZF-3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001244692.1NP_001231621.1  suppression of tumorigenicity 18 protein

      See identical proteins and their annotated locations for NP_001231621.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and it encodes the same protein as variants 2 and 3.
      Source sequence(s)
      AK122303, AK147320, BC032273
      Consensus CDS
      CCDS14810.1
      UniProtKB/Swiss-Prot
      Q3UH00, Q3URH9, Q3UVB9, Q3UZN9, Q80TY4, Q811B4, Q8K098
      UniProtKB/TrEMBL
      A5LFV3, Q148A0
      Related
      ENSMUSP00000118322.2, ENSMUST00000140079.8
      Conserved Domains (3) summary
      pfam01530
      Location:765793
      zf-C2HC; Zinc finger, C2HC type
      pfam08474
      Location:480713
      MYT1; Myelin transcription factor 1
      cl01483
      Location:9211004
      Com_YlbF; Control of competence regulator ComK, YlbF/YmcA
    2. NM_001244693.1NP_001231622.1  suppression of tumorigenicity 18 protein

      See identical proteins and their annotated locations for NP_001231622.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
      Source sequence(s)
      AK122303, AK147320, BC032273
      Consensus CDS
      CCDS14810.1
      UniProtKB/Swiss-Prot
      Q3UH00, Q3URH9, Q3UVB9, Q3UZN9, Q80TY4, Q811B4, Q8K098
      UniProtKB/TrEMBL
      A5LFV3, Q148A0
      Related
      ENSMUSP00000117789.2, ENSMUST00000131494.8
      Conserved Domains (3) summary
      pfam01530
      Location:765793
      zf-C2HC; Zinc finger, C2HC type
      pfam08474
      Location:480713
      MYT1; Myelin transcription factor 1
      cl01483
      Location:9211004
      Com_YlbF; Control of competence regulator ComK, YlbF/YmcA
    3. NM_173868.2NP_776293.1  suppression of tumorigenicity 18 protein

      See identical proteins and their annotated locations for NP_776293.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses different sequence for its 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
      Source sequence(s)
      AJ536155, AK137440
      Consensus CDS
      CCDS14810.1
      UniProtKB/Swiss-Prot
      Q3UH00, Q3URH9, Q3UVB9, Q3UZN9, Q80TY4, Q811B4, Q8K098
      UniProtKB/TrEMBL
      A5LFV3, Q148A0
      Related
      ENSMUSP00000122055.2, ENSMUST00000151281.8
      Conserved Domains (3) summary
      pfam01530
      Location:765793
      zf-C2HC; Zinc finger, C2HC type
      pfam08474
      Location:480713
      MYT1; Myelin transcription factor 1
      cl01483
      Location:9211004
      Com_YlbF; Control of competence regulator ComK, YlbF/YmcA

    RNA

    1. NR_045188.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AJ536155
    2. NR_045189.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AJ536155, BC118528

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      6557455..6931164
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036164681.1XP_036020574.1  suppression of tumorigenicity 18 protein isoform X2

      UniProtKB/Swiss-Prot
      Q3UH00, Q3URH9, Q3UVB9, Q3UZN9, Q80TY4, Q811B4, Q8K098
      UniProtKB/TrEMBL
      A5LFV3, Q148A0
      Conserved Domains (3) summary
      pfam01530
      Location:765793
      zf-C2HC; Zinc finger, C2HC type
      pfam08474
      Location:480713
      MYT1; Myelin transcription factor 1
      cl01483
      Location:9211004
      Com_YlbF; Control of competence regulator ComK, YlbF/YmcA
    2. XM_036164683.1XP_036020576.1  suppression of tumorigenicity 18 protein isoform X2

      UniProtKB/Swiss-Prot
      Q3UH00, Q3URH9, Q3UVB9, Q3UZN9, Q80TY4, Q811B4, Q8K098
      UniProtKB/TrEMBL
      A5LFV3, Q148A0
      Conserved Domains (3) summary
      pfam01530
      Location:765793
      zf-C2HC; Zinc finger, C2HC type
      pfam08474
      Location:480713
      MYT1; Myelin transcription factor 1
      cl01483
      Location:9211004
      Com_YlbF; Control of competence regulator ComK, YlbF/YmcA
    3. XM_036164670.1XP_036020563.1  suppression of tumorigenicity 18 protein isoform X1

      UniProtKB/TrEMBL
      A5LFV3
      Conserved Domains (3) summary
      pfam01530
      Location:772800
      zf-C2HC; Zinc finger, C2HC type
      pfam08474
      Location:487720
      MYT1; Myelin transcription factor 1
      cl01483
      Location:9281011
      Com_YlbF; Control of competence regulator ComK, YlbF/YmcA
    4. XM_036164682.1XP_036020575.1  suppression of tumorigenicity 18 protein isoform X2

      UniProtKB/Swiss-Prot
      Q3UH00, Q3URH9, Q3UVB9, Q3UZN9, Q80TY4, Q811B4, Q8K098
      UniProtKB/TrEMBL
      A5LFV3, Q148A0
      Related
      ENSMUSP00000131417.3, ENSMUST00000163727.4
      Conserved Domains (3) summary
      pfam01530
      Location:765793
      zf-C2HC; Zinc finger, C2HC type
      pfam08474
      Location:480713
      MYT1; Myelin transcription factor 1
      cl01483
      Location:9211004
      Com_YlbF; Control of competence regulator ComK, YlbF/YmcA
    5. XM_011238372.3XP_011236674.1  suppression of tumorigenicity 18 protein isoform X2

      See identical proteins and their annotated locations for XP_011236674.1

      UniProtKB/Swiss-Prot
      Q3UH00, Q3URH9, Q3UVB9, Q3UZN9, Q80TY4, Q811B4, Q8K098
      UniProtKB/TrEMBL
      A5LFV3, Q148A0
      Conserved Domains (3) summary
      pfam01530
      Location:765793
      zf-C2HC; Zinc finger, C2HC type
      pfam08474
      Location:480713
      MYT1; Myelin transcription factor 1
      cl01483
      Location:9211004
      Com_YlbF; Control of competence regulator ComK, YlbF/YmcA
    6. XM_030253959.1XP_030109819.1  suppression of tumorigenicity 18 protein isoform X1

      UniProtKB/TrEMBL
      A5LFV3
      Conserved Domains (3) summary
      pfam01530
      Location:772800
      zf-C2HC; Zinc finger, C2HC type
      pfam08474
      Location:487720
      MYT1; Myelin transcription factor 1
      cl01483
      Location:9281011
      Com_YlbF; Control of competence regulator ComK, YlbF/YmcA
    7. XM_030253967.1XP_030109827.1  suppression of tumorigenicity 18 protein isoform X3

      UniProtKB/TrEMBL
      A5LFV3
      Conserved Domains (3) summary
      pfam01530
      Location:730758
      zf-C2HC; Zinc finger, C2HC type
      pfam08474
      Location:445678
      MYT1; Myelin transcription factor 1
      cl01483
      Location:886969
      Com_YlbF; Control of competence regulator ComK, YlbF/YmcA
    8. XM_030253964.2XP_030109824.1  suppression of tumorigenicity 18 protein isoform X2

      UniProtKB/Swiss-Prot
      Q3UH00, Q3URH9, Q3UVB9, Q3UZN9, Q80TY4, Q811B4, Q8K098
      UniProtKB/TrEMBL
      A5LFV3, Q148A0
      Related
      ENSMUSP00000042056.7, ENSMUST00000043578.13
      Conserved Domains (3) summary
      pfam01530
      Location:765793
      zf-C2HC; Zinc finger, C2HC type
      pfam08474
      Location:480713
      MYT1; Myelin transcription factor 1
      cl01483
      Location:9211004
      Com_YlbF; Control of competence regulator ComK, YlbF/YmcA
    9. XM_006495503.5XP_006495566.1  suppression of tumorigenicity 18 protein isoform X2

      See identical proteins and their annotated locations for XP_006495566.1

      UniProtKB/Swiss-Prot
      Q3UH00, Q3URH9, Q3UVB9, Q3UZN9, Q80TY4, Q811B4, Q8K098
      UniProtKB/TrEMBL
      A5LFV3, Q148A0
      Conserved Domains (3) summary
      pfam01530
      Location:765793
      zf-C2HC; Zinc finger, C2HC type
      pfam08474
      Location:480713
      MYT1; Myelin transcription factor 1
      cl01483
      Location:9211004
      Com_YlbF; Control of competence regulator ComK, YlbF/YmcA
    10. XM_011238371.4XP_011236673.1  suppression of tumorigenicity 18 protein isoform X2

      See identical proteins and their annotated locations for XP_011236673.1

      UniProtKB/Swiss-Prot
      Q3UH00, Q3URH9, Q3UVB9, Q3UZN9, Q80TY4, Q811B4, Q8K098
      UniProtKB/TrEMBL
      A5LFV3, Q148A0
      Conserved Domains (3) summary
      pfam01530
      Location:765793
      zf-C2HC; Zinc finger, C2HC type
      pfam08474
      Location:480713
      MYT1; Myelin transcription factor 1
      cl01483
      Location:9211004
      Com_YlbF; Control of competence regulator ComK, YlbF/YmcA
    11. XM_030253957.2XP_030109817.1  suppression of tumorigenicity 18 protein isoform X1

      UniProtKB/TrEMBL
      A5LFV3
      Conserved Domains (3) summary
      pfam01530
      Location:772800
      zf-C2HC; Zinc finger, C2HC type
      pfam08474
      Location:487720
      MYT1; Myelin transcription factor 1
      cl01483
      Location:9281011
      Com_YlbF; Control of competence regulator ComK, YlbF/YmcA
    12. XM_030253968.2XP_030109828.1  suppression of tumorigenicity 18 protein isoform X3

      UniProtKB/TrEMBL
      A5LFV3
      Conserved Domains (3) summary
      pfam01530
      Location:730758
      zf-C2HC; Zinc finger, C2HC type
      pfam08474
      Location:445678
      MYT1; Myelin transcription factor 1
      cl01483
      Location:886969
      Com_YlbF; Control of competence regulator ComK, YlbF/YmcA
    13. XM_030253955.2XP_030109815.1  suppression of tumorigenicity 18 protein isoform X1

      UniProtKB/TrEMBL
      A5LFV3
      Conserved Domains (3) summary
      pfam01530
      Location:772800
      zf-C2HC; Zinc finger, C2HC type
      pfam08474
      Location:487720
      MYT1; Myelin transcription factor 1
      cl01483
      Location:9281011
      Com_YlbF; Control of competence regulator ComK, YlbF/YmcA
    14. XM_036164684.1XP_036020577.1  suppression of tumorigenicity 18 protein isoform X2

      UniProtKB/Swiss-Prot
      Q3UH00, Q3URH9, Q3UVB9, Q3UZN9, Q80TY4, Q811B4, Q8K098
      UniProtKB/TrEMBL
      A5LFV3, Q148A0
      Conserved Domains (3) summary
      pfam01530
      Location:765793
      zf-C2HC; Zinc finger, C2HC type
      pfam08474
      Location:480713
      MYT1; Myelin transcription factor 1
      cl01483
      Location:9211004
      Com_YlbF; Control of competence regulator ComK, YlbF/YmcA
    15. XM_006495501.4XP_006495564.1  suppression of tumorigenicity 18 protein isoform X2

      See identical proteins and their annotated locations for XP_006495564.1

      UniProtKB/Swiss-Prot
      Q3UH00, Q3URH9, Q3UVB9, Q3UZN9, Q80TY4, Q811B4, Q8K098
      UniProtKB/TrEMBL
      A5LFV3, Q148A0
      Conserved Domains (3) summary
      pfam01530
      Location:765793
      zf-C2HC; Zinc finger, C2HC type
      pfam08474
      Location:480713
      MYT1; Myelin transcription factor 1
      cl01483
      Location:9211004
      Com_YlbF; Control of competence regulator ComK, YlbF/YmcA
    16. XM_036164671.1XP_036020564.1  suppression of tumorigenicity 18 protein isoform X1

      UniProtKB/TrEMBL
      A5LFV3
      Conserved Domains (3) summary
      pfam01530
      Location:772800
      zf-C2HC; Zinc finger, C2HC type
      pfam08474
      Location:487720
      MYT1; Myelin transcription factor 1
      cl01483
      Location:9281011
      Com_YlbF; Control of competence regulator ComK, YlbF/YmcA
    17. XM_036164680.1XP_036020573.1  suppression of tumorigenicity 18 protein isoform X2

      UniProtKB/Swiss-Prot
      Q3UH00, Q3URH9, Q3UVB9, Q3UZN9, Q80TY4, Q811B4, Q8K098
      UniProtKB/TrEMBL
      A5LFV3, Q148A0
      Conserved Domains (3) summary
      pfam01530
      Location:765793
      zf-C2HC; Zinc finger, C2HC type
      pfam08474
      Location:480713
      MYT1; Myelin transcription factor 1
      cl01483
      Location:9211004
      Com_YlbF; Control of competence regulator ComK, YlbF/YmcA
    18. XM_030253956.1XP_030109816.1  suppression of tumorigenicity 18 protein isoform X1

      UniProtKB/TrEMBL
      A5LFV3
      Conserved Domains (3) summary
      pfam01530
      Location:772800
      zf-C2HC; Zinc finger, C2HC type
      pfam08474
      Location:487720
      MYT1; Myelin transcription factor 1
      cl01483
      Location:9281011
      Com_YlbF; Control of competence regulator ComK, YlbF/YmcA
    19. XM_011238373.3XP_011236675.1  suppression of tumorigenicity 18 protein isoform X2

      See identical proteins and their annotated locations for XP_011236675.1

      UniProtKB/Swiss-Prot
      Q3UH00, Q3URH9, Q3UVB9, Q3UZN9, Q80TY4, Q811B4, Q8K098
      UniProtKB/TrEMBL
      A5LFV3, Q148A0
      Conserved Domains (3) summary
      pfam01530
      Location:765793
      zf-C2HC; Zinc finger, C2HC type
      pfam08474
      Location:480713
      MYT1; Myelin transcription factor 1
      cl01483
      Location:9211004
      Com_YlbF; Control of competence regulator ComK, YlbF/YmcA
    20. XM_030253960.1XP_030109820.1  suppression of tumorigenicity 18 protein isoform X1

      UniProtKB/TrEMBL
      A5LFV3
      Conserved Domains (3) summary
      pfam01530
      Location:772800
      zf-C2HC; Zinc finger, C2HC type
      pfam08474
      Location:487720
      MYT1; Myelin transcription factor 1
      cl01483
      Location:9281011
      Com_YlbF; Control of competence regulator ComK, YlbF/YmcA
    21. XM_006495504.4XP_006495567.1  suppression of tumorigenicity 18 protein isoform X2

      See identical proteins and their annotated locations for XP_006495567.1

      UniProtKB/Swiss-Prot
      Q3UH00, Q3URH9, Q3UVB9, Q3UZN9, Q80TY4, Q811B4, Q8K098
      UniProtKB/TrEMBL
      A5LFV3, Q148A0
      Conserved Domains (3) summary
      pfam01530
      Location:765793
      zf-C2HC; Zinc finger, C2HC type
      pfam08474
      Location:480713
      MYT1; Myelin transcription factor 1
      cl01483
      Location:9211004
      Com_YlbF; Control of competence regulator ComK, YlbF/YmcA
    22. XM_006495502.5XP_006495565.1  suppression of tumorigenicity 18 protein isoform X2

      See identical proteins and their annotated locations for XP_006495565.1

      UniProtKB/Swiss-Prot
      Q3UH00, Q3URH9, Q3UVB9, Q3UZN9, Q80TY4, Q811B4, Q8K098
      UniProtKB/TrEMBL
      A5LFV3, Q148A0
      Conserved Domains (3) summary
      pfam01530
      Location:765793
      zf-C2HC; Zinc finger, C2HC type
      pfam08474
      Location:480713
      MYT1; Myelin transcription factor 1
      cl01483
      Location:9211004
      Com_YlbF; Control of competence regulator ComK, YlbF/YmcA
    23. XM_030253961.2XP_030109821.1  suppression of tumorigenicity 18 protein isoform X2

      UniProtKB/Swiss-Prot
      Q3UH00, Q3URH9, Q3UVB9, Q3UZN9, Q80TY4, Q811B4, Q8K098
      UniProtKB/TrEMBL
      A5LFV3, Q148A0
      Conserved Domains (3) summary
      pfam01530
      Location:765793
      zf-C2HC; Zinc finger, C2HC type
      pfam08474
      Location:480713
      MYT1; Myelin transcription factor 1
      cl01483
      Location:9211004
      Com_YlbF; Control of competence regulator ComK, YlbF/YmcA
    24. XM_030253963.2XP_030109823.1  suppression of tumorigenicity 18 protein isoform X2

      UniProtKB/Swiss-Prot
      Q3UH00, Q3URH9, Q3UVB9, Q3UZN9, Q80TY4, Q811B4, Q8K098
      UniProtKB/TrEMBL
      A5LFV3, Q148A0
      Conserved Domains (3) summary
      pfam01530
      Location:765793
      zf-C2HC; Zinc finger, C2HC type
      pfam08474
      Location:480713
      MYT1; Myelin transcription factor 1
      cl01483
      Location:9211004
      Com_YlbF; Control of competence regulator ComK, YlbF/YmcA