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    Acot3 acyl-CoA thioesterase 3 [ Mus musculus (house mouse) ]

    Gene ID: 171281, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Acot3provided by MGI
    Official Full Name
    acyl-CoA thioesterase 3provided by MGI
    Primary source
    MGI:MGI:2159619
    See related
    Ensembl:ENSMUSG00000021228 AllianceGenome:MGI:2159619
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pte2a; PTE-Ia
    Summary
    Enables fatty acyl-CoA hydrolase activity. Involved in acyl-CoA metabolic process and carboxylic acid metabolic process. Located in cytosol and peroxisome. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and respiratory system. Orthologous to human ACOT1 (acyl-CoA thioesterase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in liver adult (RPKM 11.8), kidney adult (RPKM 11.2) and 16 other tissues See more
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    Genomic context

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    See Acot3 in Genome Data Viewer
    Location:
    12 D1; 12 39.02 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (84098918..84107174)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (84052144..84060400)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_32721 Neighboring gene acyl-CoA thioesterase 1 Neighboring gene predicted gene, 40474 Neighboring gene STARR-seq mESC enhancer starr_32722 Neighboring gene acyl-CoA thioesterase 4 Neighboring gene acyl-CoA thioesterase 5 Neighboring gene acyl-CoA thioesterase 5 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning and characterization of two mouse peroxisome proliferator-activated receptor alpha (PPARalpha)-regulated peroxisomal acyl-CoA thioesterases. Westin MA, et al. J Biol Chem, 2004 May 21. PMID 15007068
    2. Peroxisome proliferator-induced long chain acyl-CoA thioesterases comprise a highly conserved novel multi-gene family involved in lipid metabolism. Hunt MC, et al. J Biol Chem, 1999 Nov 26. PMID 10567408
    3. Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs. Hunt MC, et al. FASEB J, 2006 Sep. PMID 16940157
    4. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
    5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables carboxylic ester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables fatty acyl-CoA hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables fatty acyl-CoA hydrolase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables fatty acyl-CoA hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables fatty acyl-CoA hydrolase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in acyl-CoA metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in acyl-CoA metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in acyl-CoA metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in fatty acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in long-chain fatty acid metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in long-chain fatty acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in saturated monocarboxylic acid metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in unsaturated monocarboxylic acid metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in very long-chain fatty acid metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in very long-chain fatty acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in peroxisome TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    acyl-coenzyme A thioesterase 3
    Names
    peroxisomal acyl-CoA thioesterase 2A
    peroxisomal acyl-coenzyme A thioester hydrolase 2a
    peroxisomal long-chain acyl-CoA thioesterase 2
    NP_001333630.1
    NP_599007.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001346701.1 → NP_001333630.1  acyl-coenzyme A thioesterase 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC133183
      Consensus CDS
      CCDS83985.1
      UniProtKB/TrEMBL
      A0A1Y7VML8
      Related
      ENSMUSP00000112678.2, ENSMUST00000120927.8

    2. NM_134246.3 → NP_599007.1  acyl-coenzyme A thioesterase 3 isoform 1

      See identical proteins and their annotated locations for NP_599007.1

      Status: VALIDATED

      Source sequence(s)
      AC133183
      Consensus CDS
      CCDS26036.1
      UniProtKB/Swiss-Prot
      Q6Q2Z7, Q9QYR7
      UniProtKB/TrEMBL
      A0A1Y7VML8, Q53YL1
      Related
      ENSMUSP00000021653.7, ENSMUST00000021653.8
      Conserved Domains (3) summary
      pfam04775
      Location:28 → 148
      Bile_Hydr_Trans; Acyl-CoA thioester hydrolase/BAAT N-terminal region
      pfam08840
      Location:214 → 423
      BAAT_C; BAAT / Acyl-CoA thioester hydrolase C terminal
      cl21494
      Location:148 → 264
      Abhydrolase; alpha/beta hydrolases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      84098918..84107174
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9QYR7.1 GenPept UniProtKB/Swiss-Prot:Q9QYR7

    Gene LinkOut

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