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    Arl5a ADP-ribosylation factor-like 5A [ Mus musculus (house mouse) ]

    Gene ID: 75423, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Arl5aprovided by MGI
    Official Full Name
    ADP-ribosylation factor-like 5Aprovided by MGI
    Primary source
    MGI:MGI:1922673
    See related
    Ensembl:ENSMUSG00000036093 AllianceGenome:MGI:1922673
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Arl5; 2410015N24Rik; 2810410P22Rik
    Summary
    Predicted to enable GTP binding activity. Predicted to be involved in intracellular protein transport; protein localization to Golgi membrane; and vesicle-mediated transport. Predicted to be active in trans-Golgi network. Is expressed in liver lobe; metanephros; nervous system; and vibrissa. Orthologous to human ARL5A (ADP ribosylation factor like GTPase 5A). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 6.4), CNS E18 (RPKM 6.4) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Arl5a in Genome Data Viewer
    Location:
    2 C1.1; 2 29.98 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (52287961..52314886, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (52397949..52424874, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene 13521 Neighboring gene predicted gene 13522 Neighboring gene RIKEN cDNA A430018G15 gene Neighboring gene calcium channel, voltage-dependent, beta 4 subunit Neighboring gene STARR-seq mESC enhancer starr_04483 Neighboring gene biogenesis of lysosomal organelles complex-1, subunit 2, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. An 'equalized cDNA library' by the reassociation of short double-stranded cDNAs. Ko MS. Nucleic Acids Res, 1990 Oct 11. PMID 2216762, Free PMC Article
    2. Decreased expression levels of Ifi genes is associated to the increased resistance to spontaneous arthritis disease in mice deficiency of IL-1RA. Liu X, et al. BMC Immunol, 2016 Aug 2. PMID 27480124, Free PMC Article
    3. Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Miller JA, et al. Development, 2013 Nov. PMID 24154525, Free PMC Article
    4. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein localization to Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ADP-ribosylation factor-like protein 5A
    Names
    ADP-ribosylation factor-like 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_182994.2 → NP_892039.1  ADP-ribosylation factor-like protein 5A

      See identical proteins and their annotated locations for NP_892039.1

      Status: PROVISIONAL

      Source sequence(s)
      AL845467
      Consensus CDS
      CCDS16033.1
      UniProtKB/Swiss-Prot
      Q80ZU0
      UniProtKB/TrEMBL
      Q498A0
      Related
      ENSMUSP00000041756.8, ENSMUST00000036541.8
      Conserved Domains (2) summary
      cd04153
      Location:3 → 175
      Arl5_Arl8; Arf-like 5 (Arl5) and 8 (Arl8) GTPases
      pfam00071
      Location:18 → 164
      Ras; Ras family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      52287961..52314886 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011239204.4 → XP_011237506.1  ADP-ribosylation factor-like protein 5A isoform X1

      Conserved Domains (1) summary
      cl38936
      Location:1 → 138
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80ZU0.1 GenPept UniProtKB/Swiss-Prot:Q80ZU0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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