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    Lipf lipase, gastric [ Mus musculus (house mouse) ]

    Gene ID: 67717, updated on 9-Dec-2024

    Summary

    Official Symbol
    Lipfprovided by MGI
    Official Full Name
    lipase, gastricprovided by MGI
    Primary source
    MGI:MGI:1914967
    See related
    Ensembl:ENSMUSG00000024768 AllianceGenome:MGI:1914967
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2310051B21Rik
    Summary
    Predicted to enable triacylglycerol lipase activity. Predicted to be involved in lipid catabolic process and malate metabolic process. Predicted to be located in extracellular region and mitochondrion. Predicted to be active in intracellular membrane-bounded organelle. Is expressed in body wall mesenchyme. Orthologous to human LIPF (lipase F, gastric type). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 2.3), genital fat pad adult (RPKM 0.6) and 3 other tissues See more
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    Genomic context

    See Lipf in Genome Data Viewer
    Location:
    19 C1; 19 29.29 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (33938648..33954213)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (33961248..33976813)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene nudix (nucleoside diphosphate linked moiety X)-type motif 15 pseudogene Neighboring gene STARR-seq mESC enhancer starr_45983 Neighboring gene STARR-seq mESC enhancer starr_45985 Neighboring gene predicted gene, 23095 Neighboring gene STARR-seq mESC enhancer starr_45986 Neighboring gene lipase, family member K Neighboring gene predicted gene, 31300

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables malate dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables triacylglycerol lipase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables triacylglycerol lipase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables triacylglycerol lipase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in malate metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    gastric triacylglycerol lipase
    Names
    GL
    gastric lipase
    NP_080610.1
    XP_017173769.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026334.3NP_080610.1  gastric triacylglycerol lipase precursor

      See identical proteins and their annotated locations for NP_080610.1

      Status: VALIDATED

      Source sequence(s)
      AC098875, AC102119
      Consensus CDS
      CCDS29754.1
      UniProtKB/Swiss-Prot
      Q8BK78, Q9CPP7, Q9CPP8, Q9D6L1, Q9D6L9, Q9D6M9, Q9D6N8, Q9D6P3, Q9D6Q2, Q9D6Q3, Q9D6Q6, Q9D6S5, Q9D6T5, Q9D6X0, Q9D760, Q9D766, Q9D767, Q9D796, Q9D798, Q9D7C5
      Related
      ENSMUSP00000025680.5, ENSMUST00000025680.5
      Conserved Domains (1) summary
      PLN02872
      Location:35389
      PLN02872; triacylglycerol lipase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      33938648..33954213
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017318280.1XP_017173769.1  gastric triacylglycerol lipase isoform X1

      UniProtKB/Swiss-Prot
      Q8BK78, Q9CPP7, Q9CPP8, Q9D6L1, Q9D6L9, Q9D6M9, Q9D6N8, Q9D6P3, Q9D6Q2, Q9D6Q3, Q9D6Q6, Q9D6S5, Q9D6T5, Q9D6X0, Q9D760, Q9D766, Q9D767, Q9D796, Q9D798, Q9D7C5
      Conserved Domains (1) summary
      PLN02872
      Location:35389
      PLN02872; triacylglycerol lipase