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    Trpc3 transient receptor potential cation channel, subfamily C, member 3 [ Mus musculus (house mouse) ]

    Gene ID: 22065, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Trpc3provided by MGI
    Official Full Name
    transient receptor potential cation channel, subfamily C, member 3provided by MGI
    Primary source
    MGI:MGI:109526
    See related
    Ensembl:ENSMUSG00000027716 AllianceGenome:MGI:109526
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mwk; Trp3; Trcp3; Trrp3
    Summary
    Predicted to enable calcium-activated cation channel activity; inositol 1,4,5 trisphosphate binding activity; and store-operated calcium channel activity. Predicted to be involved in several processes, including positive regulation of calcium ion transport into cytosol; positive regulation of cardiac muscle hypertrophy in response to stress; and response to ATP. Predicted to be part of cation channel complex. Predicted to be active in plasma membrane. Is expressed in several structures, including cochlea; ganglia; skeletal muscle; spinal cord; and trunk somite. Human ortholog(s) of this gene implicated in cerebellar ataxia type 41. Orthologous to human TRPC3 (transient receptor potential cation channel subfamily C member 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in cerebellum adult (RPKM 16.9), CNS E18 (RPKM 4.1) and 11 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Trpc3 in Genome Data Viewer
    Location:
    3 B; 3 17.93 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (36674626..36744276, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (36620482..36690429, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2068 Neighboring gene exosome component 9 Neighboring gene STARR-seq mESC enhancer starr_07426 Neighboring gene cyclin A2 Neighboring gene Bardet-Biedl syndrome 7 Neighboring gene predicted gene, 35856 Neighboring gene STARR-seq mESC enhancer starr_07428 Neighboring gene protein tyrosine phosphatase, mitochondrial 1 pseudogene Neighboring gene bridge-like lipid transfer protein family member 1 Neighboring gene STARR-seq mESC enhancer starr_07429 Neighboring gene STARR-seq mESC enhancer starr_07431

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. TRPC3 channels critically regulate hippocampal excitability and contextual fear memory. Neuner SM, et al. Behav Brain Res, 2015 Mar 15. PMID 25513972, Free PMC Article
    2. Alternative splicing of the TRPC3 ion channel calmodulin/IP3 receptor-binding domain in the hindbrain enhances cation flux. Kim Y, et al. J Neurosci, 2012 Aug 15. PMID 22895723, Free PMC Article
    3. Vascular smooth muscle TRPC3 channels facilitate the inverse hemodynamic response during status epilepticus. Cozart MA, et al. Sci Rep, 2020 Jan 21. PMID 31964991, Free PMC Article
    4. Manganese inhibits ATP-induced calcium entry through the transient receptor potential channel TRPC3 in astrocytes. Streifel KM, et al. Neurotoxicology, 2013 Jan. PMID 23131343, Free PMC Article
    5. TRPC3 deficiency attenuates high salt-induced cardiac hypertrophy by alleviating cardiac mitochondrial dysfunction. Ma T, et al. Biochem Biophys Res Commun, 2019 Nov 19. PMID 31543348

    See all (174) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Enhanced TRPC3 transcription through AT1R/PKA/CREB signaling contributes to mitochondrial dysfunction in renal tubular epithelial cells in D-galactose-induced accelerated aging mice.
      Title: Enhanced TRPC3 transcription through AT1R/PKA/CREB signaling contributes to mitochondrial dysfunction in renal tubular epithelial cells in D-galactose-induced accelerated aging mice.
    2. New insights in the renal distribution profile of TRPC3 - Of mice and men.
      Title: New insights in the renal distribution profile of TRPC3 - Of mice and men.
    3. Canonical Transient Receptor Potential Channel 3 Contributes to Cerebral Blood Flow Changes Associated with Cortical Spreading Depression in Mice.
      Title: Canonical Transient Receptor Potential Channel 3 Contributes to Cerebral Blood Flow Changes Associated with Cortical Spreading Depression in Mice.
    4. Role of TRPC3 in Right Ventricular Dilatation under Chronic Intermittent Hypoxia in 129/SvEv Mice.
      Title: Role of TRPC3 in Right Ventricular Dilatation under Chronic Intermittent Hypoxia in 129/SvEv Mice.
    5. Sensory neuron-expressed TRPC3 mediates acute and chronic itch.
      Title: Sensory neuron-expressed TRPC3 mediates acute and chronic itch.
    6. TRPC3 Regulates Islet Beta-Cell Insulin Secretion.
      Title: TRPC3 Regulates Islet Beta-Cell Insulin Secretion.
    7. Ablation of TRPC3 compromises bicarbonate and phosphate transporter activity in mice proximal tubular cells.
      Title: Ablation of TRPC3 compromises bicarbonate and phosphate transporter activity in mice proximal tubular cells.
    8. Increase in membrane surface expression and phosphorylation of TRPC3 related to olfactory dysfunction in alpha-synuclein transgenic mice.
      Title: Increase in membrane surface expression and phosphorylation of TRPC3 related to olfactory dysfunction in α-synuclein transgenic mice.
    9. Sodium-Glucose Cotransporter 2 Inhibitor Canagliflozin Antagonizes Salt-Sensitive Hypertension Through Modifying Transient Receptor Potential Channels 3 Mediated Vascular Calcium Handling.
      Title: Sodium-Glucose Cotransporter 2 Inhibitor Canagliflozin Antagonizes Salt-Sensitive Hypertension Through Modifying Transient Receptor Potential Channels 3 Mediated Vascular Calcium Handling.
    10. A TRPC3/6 Channel Inhibitor Promotes Arteriogenesis after Hind-Limb Ischemia.
      Title: A TRPC3/6 Channel Inhibitor Promotes Arteriogenesis after Hind-Limb Ischemia.
    Submit: New GeneRIF Correction See all GeneRIFs (91)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC124333

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium-activated cation channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium-activated cation channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables inositol 1,4,5 trisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables inositol 1,4,5 trisphosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables inositol 1,4,5 trisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables store-operated calcium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables store-operated calcium channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in calcium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in calcium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in calcium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of calcium ion transport into cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of calcium ion transport into cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cardiac muscle hypertrophy in response to stress IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cardiac muscle hypertrophy in response to stress ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cytosolic calcium ion concentration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to ATP IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to ATP ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to calcium ion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to calcium ion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in single fertilization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of cation channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    short transient receptor potential channel 3
    Names
    TRP-3
    mTrp3
    receptor-activated cation channel TRP3
    transient receptor protein 3
    trp-related protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001403842.1 → NP_001390771.1  short transient receptor potential channel 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC117584
      UniProtKB/TrEMBL
      E6Y6Q0

    2. NM_019510.3 → NP_062383.2  short transient receptor potential channel 3 isoform 1

      See identical proteins and their annotated locations for NP_062383.2

      Status: VALIDATED

      Source sequence(s)
      AC117584
      Consensus CDS
      CCDS50893.1
      UniProtKB/Swiss-Prot
      B1ATV3, Q61058, Q9QZC1
      UniProtKB/TrEMBL
      Q8CCQ1
      Related
      ENSMUSP00000029271.5, ENSMUST00000029271.5
      Conserved Domains (4) summary
      cd00204
      Location:108 → 242
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      TIGR00870
      Location:85 → 879
      trp; transient-receptor-potential calcium channel protein
      pfam08344
      Location:256 → 315
      TRP_2; Transient receptor ion channel II
      sd00045
      Location:135 → 166
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      36674626..36744276 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9QZC1.2 GenPept UniProtKB/Swiss-Prot:Q9QZC1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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