Chil4 chitinase-like 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Chil4provided by MGI
Official Full Name: chitinase-like 4provided by MGI
Primary source: MGI:MGI:1341098
See related: Ensembl:ENSMUSG00000063779 AllianceGenome:MGI:1341098
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ym2; Chi3l4
Summary: Predicted to enable chitin binding activity; chitinase activity; and kinase binding activity. Predicted to be involved in chitin catabolic process; positive regulation of chemokine production; and production of molecular mediator involved in inflammatory response. Located in cytoplasm. Is expressed in several structures, including alimentary system; genitourinary system; liver; lung; and smooth muscle tissue. Human ortholog(s) of this gene implicated in asthma. Orthologous to human CHIA (chitinase acidic). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in stomach adult (RPKM 19.9), lung adult (RPKM 8.8) and 1 other tissue See more
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Genomic context

Location:: 3 F2.2; 3 46.49 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (106108807..106126795, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (106201491..106219479, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Chitinase-Like Protein Ym2 (Chil4) Regulates Regeneration of the Olfactory Epithelium via Interaction with Inflammation.
Title: Chitinase-Like Protein Ym2 (Chil4) Regulates Regeneration of the Olfactory Epithelium via Interaction with Inflammation.
Production of Ym1/2 in response to interleukin-13 promotes T helper type (Th)2 cell cytokine production and allergic airway inflammation by inhibiting the production of 12(S)-hydroxyeicosatetraenoic acid (HETE) by 12/15(S)-lipoxygenase (LOX).
Title: Ym1/2 promotes Th2 cytokine expression by inhibiting 12/15(S)-lipoxygenase: identification of a novel pathway for regulating allergic inflammation.
Induced only in the presence of IL-4.
Title: Induction of Ym1/2 in mouse bone marrow-derived mast cells by IL-4 and identification of Ym1/2 in connective tissue type-like mast cells derived from bone marrow cells cultured with IL-4 and stem cell factor.
Quantitative RT-PCR demonstrated a 976-fold increase of Chi3l4 mRNA expression and a 24-fold increase of Chi3l3 mRNA expression in the skin of cpdm/cpdm mice.
Title: Expression of chitinase-like proteins in the skin of chronic proliferative dermatitis (cpdm/cpdm) mice.
The eosinophilic protein Ym2 (chitinase 3-like 4) was isolated from characteristic hyaline gastric lesion mainly found in female CYP1A2-null mice. The relation between Ym2 and CYP1A2 is unknown.
Title: Hyalinosis and Ym1/Ym2 gene expression in the stomach and respiratory tract of 129S4/SvJae and wild-type and CYP1A2-null B6, 129 mice.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables chitin binding	IBA Inferred from Biological aspect of Ancestor more info
enables chitin binding	IEA Inferred from Electronic Annotation more info
enables chitinase activity	ISO Inferred from Sequence Orthology more info
enables kinase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in chitin catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in chitin catabolic process	ISO Inferred from Sequence Orthology more info
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of chemokine production	ISO Inferred from Sequence Orthology more info
involved_in production of molecular mediator involved in inflammatory response	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular region	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: chitinase-like protein 4

Names: chitinase 3-like 4, Chil4; chitinase-3-like protein 4; secreted protein Ym2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_145126.2 → NP_660108.2 chitinase-like protein 4 precursor

See identical proteins and their annotated locations for NP_660108.2

Status: VALIDATED

Source sequence(s)

AK131914

Consensus CDS

CCDS17719.1

UniProtKB/Swiss-Prot

Q3V2C9, Q8VH43, Q8VHG1, Q91Z98

Related

ENSMUSP00000080851.6, ENSMUST00000082219.6

Conserved Domains (2) summary

cd02872
Location:24 → 387

GH18_chitolectin_chitotriosidase; This conserved domain family includes a large number of catalytically inactive chitinase-like lectins (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1, oviductin, and AMCase (acidic mammalian chitinase), as well as catalytically active ...

smart00636
Location:26 → 365

Glyco_18; Glyco_18 domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

106108807..106126795 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036162802.1 → XP_036018695.1 chitinase-like protein 4 isoform X1

Conserved Domains (1) summary

cd02872
Location:2 → 363

GH18_chitolectin_chitotriosidase; This conserved domain family includes a large number of catalytically inactive chitinase-like lectins (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1, oviductin, and AMCase (acidic mammalian chitinase), as well as catalytically active ...