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    B3gnt6 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6 [ Mus musculus (house mouse) ]

    Gene ID: 272411, updated on 9-Dec-2024

    Summary

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    Official Symbol
    B3gnt6provided by MGI
    Official Full Name
    UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6provided by MGI
    Primary source
    MGI:MGI:3039603
    See related
    Ensembl:ENSMUSG00000074004 AllianceGenome:MGI:3039603
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Core3; Core-3
    Summary
    Predicted to enable UDP-glycosyltransferase activity and galactosyltransferase activity. Predicted to be involved in poly-N-acetyllactosamine biosynthetic process and protein O-linked glycosylation. Predicted to be active in Golgi membrane. Orthologous to human B3GNT6 (UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in colon adult (RPKM 47.3) and large intestine adult (RPKM 2.1) See more
    Orthologs
    human all
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    Genomic context

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    See B3gnt6 in Genome Data Viewer
    Location:
    7 E1; 7 53.63 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (97841622..97848682, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (98192415..98199475, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene calpain 5 Neighboring gene olfactory marker protein Neighboring gene STARR-positive B cell enhancer mm9_chr7:105326664-105326964 Neighboring gene STARR-seq mESC enhancer starr_19624 Neighboring gene predicted gene, 16938 Neighboring gene alkaline ceramidase 3 Neighboring gene STARR-seq mESC enhancer starr_19625 Neighboring gene STARR-seq mESC enhancer starr_19626 Neighboring gene STARR-positive B cell enhancer mm9_chr7:105457877-105458178 Neighboring gene STARR-seq mESC enhancer starr_19627 Neighboring gene tsukushi, small leucine rich proteoglycan

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Evidence of functional cross talk between the Notch and NF-κB pathways in nonneoplastic hyperproliferating colonic epithelium. Ahmed I, et al. Am J Physiol Gastrointest Liver Physiol, 2013 Feb 15. PMID 23203159, Free PMC Article
    2. Role of mucin glycosylation in the gut microbiota-brain axis of core 3 O-glycan deficient mice. Coletto E, et al. Sci Rep, 2023 Aug 26. PMID 37634035, Free PMC Article
    3. Increased susceptibility to colitis and colorectal tumors in mice lacking core 3-derived O-glycans. An G, et al. J Exp Med, 2007 Jun 11. PMID 17517967, Free PMC Article
    4. Loss of intestinal O-glycans promotes spontaneous duodenal tumors. Gao N, et al. Am J Physiol Gastrointest Liver Physiol, 2016 Jul 1. PMID 27229122, Free PMC Article
    5. The mucin Muc2 limits pathogen burdens and epithelial barrier dysfunction during Salmonella enterica serovar Typhimurium colitis. Zarepour M, et al. Infect Immun, 2013 Oct. PMID 23876803, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables UDP-glycosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables galactosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables galactosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables galactosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in poly-N-acetyllactosamine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein O-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase
    Names
    BGnT-6
    beta-1,3-Gn-T6
    beta-1,3-N-acetylglucosaminyltransferase 6
    beta3Gn-T6
    core 3 synthase
    NP_001074636.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081167.1 → NP_001074636.1  acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase

      See identical proteins and their annotated locations for NP_001074636.1

      Status: PROVISIONAL

      Source sequence(s)
      AC119880
      Consensus CDS
      CCDS40027.1
      UniProtKB/Swiss-Prot
      Q3USF0
      Related
      ENSMUSP00000095879.3, ENSMUST00000098278.4
      Conserved Domains (1) summary
      cl21608
      Location:126 → 318
      Galactosyl_T; Galactosyltransferase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      97841622..97848682 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3USF0.2 GenPept UniProtKB/Swiss-Prot:Q3USF0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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